中华放射医学与防护杂志

耿进朝,周玉荣,刘晋红,等.乳腺癌的ER、PR、C-erbB-2和P53表达与钼靶X线表现相关性研究[J].中华放射医学与防护杂志,2006,26(5):486-489.GENG Jin-chao,ZHOU Yu-rong,LIU Jin-hong,et al.Correlativity study on ER,PR,C-erbB-2, P53, and mammography of breast cancer[J].Chin J Radiol Med Prot,2006,26(5):486-489

乳腺癌的ER、PR、C-erbB-2和P53表达与钼靶X线表现相关性研究

Correlativity study on ER,PR,C-erbB-2, P53, and mammography of breast cancer

投稿时间：2006-04-01

DOI：

中文关键词: 乳腺肿瘤钼靶X线免疫组织化学

英文关键词:Breast neoplasms Mammography Immunohistochemistry

基金项目:

作者	单位
耿进朝	100016 北京, 清华大学第一附属医院放射影像科
周玉荣	100016 北京, 清华大学第一附属医院放射影像科
刘晋红	100016 北京, 清华大学第一附属医院放射影像科
翁艳	100016 北京, 清华大学第一附属医院放射影像科
李明山	100016 北京, 清华大学第一附属医院放射影像科
刘晶哲	100016 北京, 清华大学第一附属医院放射影像科

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中文摘要:

目的探讨乳腺癌的ER、PR、C-erbB-2和P53表达与钼靶X线表现之间的相关性。方法对66例原发性乳腺癌患者术前行乳腺钼靶X线形态学分析,术后标本行免疫组织化学染色测定癌细胞ER、PR、C-erbB-2和P53表达情况,并分析与钼靶X线表现之间的关系。结果 66例乳腺癌中,癌肿毛刺状边缘与癌细胞ER阳性表达之间呈正相关关系(P<0.01);乳腺癌钙化与癌细胞C-erbB-2和P53阳性表达之间呈正相关关系(P<0.01),而与癌细胞ER和PR阳性表达水平之间呈负相关(P<0.01);乳腺癌结构紊乱与癌细胞ER阳性表达水平之间呈负相关(P<0.01),而与PR、C-erbB-2和P53阳性表达水平之间均无明显相关性;淋巴结转移与癌细胞ER和PR阳性表达之间呈正相关关系(P<0.01)。结论乳腺癌的钼靶X线表现与ER、PR、C-erbB-2和P53表达之间存在一定相关性,可根据乳腺癌钼靶X线表现对癌灶的生物学行为和预后进行评估。

英文摘要:

Objective To investigate the correlativity among the expression of ER,PR,C-erbB-2, P53, and mammography of breast cancer. Methods Mammography was performed and the morphologic features were analyzed in 66 patients with breast cancer before the operation. The mastectomy specimens of the breast neoplasm were stained with immunohistochemistry, and the expressions of estrogen receptor(ER), progesterone receptor(PR), C-erbB-2 and P53 were measured. The pathologic results were compared with mammography features. Results Among the 66 cases of breast cancers, ER positive expression was positively correlated with the spiculate margin of breast cancer(P<0.01). C-erbB-2 and P53 positive expression were positively correlated (P< 0.01). Moreover, ER and PR positive expression showed a significant inverse correlation with the calcifying of breast cancer(P<0.01). ER positive expression showed a significant inverse correlation(P<0.01),PR, C-erbB-2 and P53 positive expression was not significantly correlated with the configuration turbulence of breast cancer. ER and PR positive expression was positively correlated with the transfer of lymph(P<0.01). Conclusions There are some correlation among mammography morphologic features, ER,PR,C-erbB-2 and P53 factors in breast cancer. The biologic behavior and prognosis of the breast cancer can be assessed according to mammography features.

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