| 高宏,李力军,封国生,等.125I粒子与缓释化疗粒子联合应用靶向治疗复发性直肠癌[J].中华放射医学与防护杂志,2006,26(4):381-382.GAO Hong,LI li-jun,FENG Guo-sheng,et al.Radiochemotherapy with interstitial implantation of 125I seeds and 5-FU slow-released seeds for recurrent colorectal adenocarcinoma[J].Chin J Radiol Med Prot,2006,26(4):381-382 |
| 125I粒子与缓释化疗粒子联合应用靶向治疗复发性直肠癌 |
| Radiochemotherapy with interstitial implantation of 125I seeds and 5-FU slow-released seeds for recurrent colorectal adenocarcinoma |
| 投稿时间：2006-01-08 |
| DOI： |
| 中文关键词: 直肠肿瘤 125I粒子 氟尿嘧啶缓释化疗粒子 近距离治疗 |
| 英文关键词:Colorectal carcinoma 125I seeds 5-FU slow-release seeds Brachytherapy |
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| 摘要点击次数: 3431 |
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| 中文摘要: |
| 目的 探讨应用放、化疗粒子联合植入法综合治疗复发性直肠癌的可行性、安全性及短期疗效。方法 自2001年12月至2005年12月,应用放、化疗粒子联合植入法综合治疗复发性直肠癌26例,均为直肠癌Mile's术后盆腔复发病人。在治疗计划指导下,交替植入氟尿嘧啶缓释化疗粒子和放射性125I粒子。放射性粒子的肿瘤匹配周边剂量(matched peripheral dose,MPD)为90～130Gy。平均每例使用125I粒子12粒,氟尿嘧啶600mg。结果 26例病人手术均顺利完成,未发生出血、感染等并发症,经盆腔摄片证实放射性粒子的位置无变化。疼痛缓解率为88.9%(16/18),平均疼痛缓解时间为5～10d。于术后3～6个月CT复查肿瘤变化,提示瘤体不同程度缩小,其中2例完全缓解,19例部分缓解,4例稳定,局部控制率为81%。随访6～42个月,中位生存期为29个月,最长1例随访时间为术后42个月,现仍存活。1例术后6个月死于全身广泛转移。结论 放射性125I粒子和氟尿嘧啶缓释化疗粒子联合应用局部植入技术具有安全、微创及并发症发生率低的特点,是综合治疗复发性直肠癌较有效的手段之一。 |
| 英文摘要: |
| Objective To investigate the feasibility, security, and short-term efficacy of combined treatment of interstitial implantation of 125I seeds and 5-FU slow-released seeds for recurrent colorectal adenocarcinoma. Methods From December 2001 to December 2005, 26 cases of recurrent colorectal adenocarcinoma underwent Mile's procedure were treated with the radiochemotherapy.We implanted alternately 125I seeds and 5-FU slow-released seeds following the treatment planning system.The matched peripheral dose (MPD) of 125I seed implantation was 90-130 Gy. Twelve granules of 125I seeds and 600 mg of 5-FU were administered in every patient on average. Results No operation-related complication was occurred during the implantations for all the cases. No displacement of 125I seed was found by pelvic X-ray examination.Lenitive rate of the pain was 88.9% (16/18).The relief has lasted for 5-10 days on average. CT scanning showed that the size of tumor reduced in various degree at 3-6 months after the implantation.The complete recovery rate was 7.7% (2/26), the partial recovery rate was 73.1% (19/26).The PD was 15.4% (4/26).The median survival time was 29 months estimated by following these cases for 6-42 months. One case died of bone and lung metastases at 6 months after the implantation. Conclusion Combined radiochemotherapy with interstitial implantation of 125I seeds and 5-FU slow-released seeds was a safe and effective microinvasive treatment for recurrent colorectal carcinoma. |
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