中华放射医学与防护杂志

李志强,乐嘉宜,瞿益华,等.⁶⁰Co γ射线照射与去白细胞血血浆部分细胞因子含量变化的研究[J].中华放射医学与防护杂志,2006,26(4):349-351.LI Zhi-qiang,YUE Jia-yi,QU Yi-hua,et al.Study on changes of the plasma cytokines in ⁶⁰Co γ-ray irradiated blood and leukocyte reduction of whole blood[J].Chin J Radiol Med Prot,2006,26(4):349-351

⁶⁰Co γ射线照射与去白细胞血血浆部分细胞因子含量变化的研究

Study on changes of the plasma cytokines in ⁶⁰Co γ-ray irradiated blood and leukocyte reduction of whole blood

投稿时间：2005-10-18

DOI：

中文关键词: ⁶⁰Co γ射线照射去白细胞过滤器血液细胞因子

英文关键词:⁶⁰Co γ-ray Irradiation Leukocyte reduction sets Blood Cytokine

基金项目:上海市卫生局科技发展基金资助项目(034054)

作者	单位
李志强	200233, 上海交通大学附属第六人民医院
乐嘉宜	上海黄浦区中西医结合医院
瞿益华	200233, 上海交通大学附属第六人民医院
徐文皓	200233, 上海交通大学附属第六人民医院

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中文摘要:

目的探讨⁶⁰Co γ射线照射与去白细胞血血浆IL-2、IL-6、INF-γ与TNF-α含量的变化和患者输注后的发热情况。方法应用ELISA法检测经⁶⁰Coγ射线照射与去白细胞过滤血血浆IL-2、IL-6、INF-γ和TNF-α的含量。结果随着保存期的延长,经⁶⁰Coγ射线照射与去白细胞过滤血血浆IL-2、IL-6、INF-γ和TNF-α含量变化不很明显;并经⁶⁰Coγ射线照射或去白细胞过滤血液给患者输注后的发热现象均明显减少。结论 ⁶⁰Coγ射线照射血液制品输注在有效预防输血相关性移植物抗宿主病的同时也能有效减少非溶血性发热输血反应的发生。

英文摘要:

Objective To study the changes of IL-2,IL-6,IFN-γ and TNF-α in ⁶⁰Coγ -ray irradiated and leukocyte reduction of whole blood, and to understand the fever phenomenon in patients received blood transfusion. Methods ELISA method was used to measure changes of the cytokines. Results The plasma levels of IL-2,IL-6,IFN-γ and TNF-α did not change significantly with extending the conservation period both in ⁶⁰Coγ -irradiated and leukocyte reduction of whole blood. The frequency of fever decreaed obviously with transfusion of ⁶⁰Coγ -irradiated and leukocyte reduction of whole blood. Conclusion ⁶⁰Coγ -irradiated blood can not only prevent transfusion associated graft-versus-host disease(TA-GVHD), but also decrease non-hemolytic febrile transfusion reactions (NHFTR) effectively.

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