| 占宏伟,俞小玲,叶小娟,等.153Sm-EDTMP致血液学毒性的多因素分析[J].中华放射医学与防护杂志,2006,26(1):72-74.ZHAN Hong-wei,YU Xiao-ling,YE Xiao-juan,et al.Multi-factor analysis on events related to hematological toxicity in 153Sm-EDTMP palliative therapy for skeletal metastases[J].Chin J Radiol Med Prot,2006,26(1):72-74 |
| 153Sm-EDTMP致血液学毒性的多因素分析 |
| Multi-factor analysis on events related to hematological toxicity in 153Sm-EDTMP palliative therapy for skeletal metastases |
| 投稿时间：2005-11-15 |
| DOI： |
| 中文关键词: 153Sm-乙二胺四甲撑膦酸 血液学毒性 因素分析 次数 |
| 英文关键词:153Sm-EDTMP Hematological toxicity Factor analysis Times |
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| 中文摘要: |
| 目的 探讨153Sm-乙二胺四甲撑膦酸(153Sm-EDTMP)治疗导致白细胞、血小板降低发生的相关因素。方法回顾性地整理206例153Sm-EDTMP治疗后患者的资料,运用Logistic回归对数据进行单因素和多因素分析,对有意义的指标进行分析。结果 单因素分析结果表明:153Sm-EDTMP治疗后,血液学毒性的发生与患者的年龄、骨转移灶数目、治疗前化疗史、同时进行外放疗、治疗次数有关;多因素分析结果显示,治疗前化疗史、同时进行外放疗、治疗次数等因素与血液学毒性产生与否有关;治疗前靠药物维持正常血象者也易出现血液学毒性。结论 153Sm-EDTMP治疗后血液学毒性的发生与几个因素有关,对有这些因素的患者,应特别注意治疗后血象的变化。 |
| 英文摘要: |
| Objective To investigate the clinical factors related to hematological toxicity induced by intravenous samarium-153 ethylenediaminetetramethylene phosphonic acid( 153Sm-EDTMP) treatment. Methods (A total of) 206 patients with bony metastases treated with 153Sm-EDTMP were retrospectively analyzed.Logistic regression(SPSS 10.0 for Windows) and correlation analysis were used to evaluate the factors concerned. Results Age of the patient,number of bone metastatic lesion,chemotherapy before 153Sm-EDTMP therapy,concurrent radiotherapy and repeat-times of 153Sm-EDTMP treatments were found the individual factors related to hematological toxicity.Chemotherapy before 153Sm-EDTMP,concurrent radiotherapy,medication for normal blood counting and repeat-times of 153Sm-EDTMP treatments were the hematological toxicity factors in multi-factor analysis. Conclusion In 153Sm-EDTMP therapy,several factors were found related to hematological toxicity suggesting more attention be paid to the change of blood cell counting after the palliative therapy. |
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