中华放射医学与防护杂志

石根明,徐勤,杨以理,等.甲亢手术与丙基硫氧嘧啶对¹³¹I疗效的影响[J].中华放射医学与防护杂志,2006,26(1):68-70.SHI Gen-ming,XU Qin,YANG Yi-li,et al.Iufluence of surgical or propylthiouracil pretreatment on the efficacy of iodine-131 therapy in hyperthyroidism[J].Chin J Radiol Med Prot,2006,26(1):68-70

甲亢手术与丙基硫氧嘧啶对¹³¹I疗效的影响

Iufluence of surgical or propylthiouracil pretreatment on the efficacy of iodine-131 therapy in hyperthyroidism

投稿时间：2005-08-08

DOI：

中文关键词: 甲状腺功能亢进丙基硫氧嘧啶外科治疗 ¹³¹I

英文关键词:Hyperthyroidism Propylthiouracil Surgical treatment Iodine-131

基金项目:浙江省教育厅基金资助项目(20030237)

作者	单位	E-mail
石根明	310003 杭州,浙江大学医学院附属第一医院化疗科	xuqing8@hotmail.com
徐勤	310003 杭州,浙江大学医学院附属第一医院化疗科
杨以理	310003 杭州,浙江大学医学院附属第一医院化疗科
叶安方	310003 杭州,浙江大学医学院附属第一医院化疗科
朱诚忆	310003 杭州,浙江大学医学院附属第一医院化疗科

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中文摘要:

目的探讨甲亢术后复发和丙基硫氧嘧啶(PTU)治疗后对¹³¹I疗效的影响。方法 2003年1月至2004年12月在我院核医学科治疗的甲亢术后复发病人,未经过抗甲状腺药物治疗41例为术后复发组;按同时期¹³¹I治疗次序编号,从未经过手术及抗甲状腺药物治疗的病例中随机抽取41例为对照组(未治疗组);从只经PTU治疗的病例中随机抽取41例为PTU组,采用标准剂量法给予¹³¹I治疗,分析治疗后3与6个月随访资料。结果未治疗组¹³¹I治疗后3和6个月甲亢治愈率分别为90.24%(37/41)和92.68%(38/41),无效率分别为9.76%(4/41)和7.32%(3/41);PTU治疗组¹³¹I治疗后3和6个月甲亢治愈率分别为43.90%(18/41)和53.66%(22/41),无效率分别为56.10%(23/41)和46.34%(19/41),与未治疗组比较均为P<0.01;术后复发组¹³¹I治疗后3和6个月甲亢治愈率分别为68.29%(28/41)和70.73%(29/41),无效率分别为31.71%(13/41)和29.27%(12/41),与未治疗组比较均为P<0.05。结论甲亢在¹³¹I治疗前经外科手术或PTU治疗,将影响¹³¹I治疗效果,降低甲亢¹³¹I的治愈率。

英文摘要:

Objective To investigate the influence of surgical or propylthiouracil(PTU) pretreatment on the efficacy of radioactive iodine therapy in hyperthyroidism. Methods A group(group 1) of 41 hyperthyroidism patients relapsed after surgery were treated with ¹³¹I in our department from 2003 through 2004. During that period,another group(group 2) of 41 cases were selected randomly from patients untreated either surgically or chemically before oral administration of ¹³¹I,and a third group(group 3) of 41 cases were selected randomly from those pretreated only with PTU.We analysed the results of these three groups of patients after followed_up for 3 and 6 months separately after ¹³¹I therapy. Results Approximately 90.24%(37/41 cases) and 92.68%(38/41 cases) of patients in group 2 without any pretreatment were cured 3 months and 6 months after ¹³¹I treatment,respectively,and 9.76%(4/41 cases) and 7.32%(3/41 cases) of them did not respond to ¹³¹I treatment.About 43.90%(18/41 cases) and 53.66%(22/41 cases) of patients pretreated with PTU(group 3)were cured at 3 and 6 months,respectively,and approximately 56.10%(23/41 cases) and 46.34%(19/41 cases) of this group patients did not respond to ¹³¹I treatment at 3 and 6 months,respectively(P<0.01) compared with the un_pretreated group.About 68.29%(28/41 cases) and 70.73%(29/41 cases) of relapsed patients after surgery(group 1) were cured at 3 and 6 months after ¹³¹I treatment,respectively,and 31.71%(13/41) and 29.27%(12/41) of them did not respond to ¹³¹I treatment(P<0.05) as compared with the unpretreated group. Conclusion (Surgery or PTU) pretreatment of hyperthyroidism patient before ¹³¹I treatment can affect the efficacy of ¹³¹I therapy,resulting in reduction of the cure rate.

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