| 张淑兰,克晓燕,贾廷珍.医源性急性放射病的抗感染治疗[J].中华放射医学与防护杂志,2006,26(1):20-22.ZHANG Shu-lan,KE Xiao-yan,JIA Ting-zhen.Anti-infection treatment of iatrogenic acute radiation sickness[J].Chin J Radiol Med Prot,2006,26(1):20-22 |
| 医源性急性放射病的抗感染治疗 |
| Anti-infection treatment of iatrogenic acute radiation sickness |
| 投稿时间：2005-09-28 |
| DOI： |
| 中文关键词: 医源性急性放射病 造血干细胞 全身照射 抗感染治疗 |
| 英文关键词:Iatrogenic acute radiation sickness Hemopoietic stem cell TBI Anti-infection |
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| 中文摘要: |
| 目的 总结医源性急性放射病抗感染治疗经验,为事故性放射病抗感染治疗提供借鉴。方法 观察17例大剂量照射预处理的外周血干细胞移植患者外周血象、体温、症状其抗感染后的变化。结果 照后第8~10天白细胞<1×109/L,未用rhG-CSF者白细胞持续低值为13.3d,29%的患者体温>38.5℃,经无菌处理和强有力的抗感染治疗,均未出现典型的急性放射病极期临床表现。结论 回输自体外周血干细胞和应用rhG-CSF缩短了骨髓重建时间;严格实行全环境保护和应用防治结合,合理、足量的应用抗生素是其顺利渡过放射病极期,减少合并症的关键。 |
| 英文摘要: |
| Objective To occumulatle experience of anti-infection treatment in acute radiation sickness（ARS）induced by medical treatment in order to provide beneficial help for victims of accidental of acute radiation sickness. Methods The changes of peripheral blood indices,body temperature and clinical symptoms of 17 cases who were clinically irradiated with 6.0-7.2 Gy X-rays were observed both before peripheral blood stem cell transplantation（PBSCT） and after anti-infection treatment. Results WBC count began to decrease to below 1×109/L from the 8th to 10th days after irradiation and maintained at low level for 4 days or for 13.3 days if the patients had not received rhG-CSF treatment.In 29.4% of patients the body temperature was higher than 38.5℃.After comprehensive enviromental protection and anti-infection treatment,all patients could successfully tide over the period of bone marrow depression without appearance of the typical critical phase of ARS. Conclusion PBSCT and rhG-CSF treatment can reduce the time span for reconstruction of bone marrow.Comprehensive enviromental protection and combined anti-infection treatment are key points for successful treatment. |
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