| 乔学英,周道安,高献书,韩春,平育敏,杨香然,万钧.外照射加腔内照射治疗食管癌的前瞻性研究[J].中华放射医学与防护杂志,2005,25(6):547-550 |
| 外照射加腔内照射治疗食管癌的前瞻性研究 |
| A prospective clinical study of intracavitary brachytherapy combined with external beam irradiation for esophageal carcinoma |
| 投稿时间：2004-12-12 |
| DOI： |
| 中文关键词: 食管癌 放射疗法 近距离放射疗法 |
| 英文关键词:Esophageal neoplasms Radiotherapy Brachytherapy |
| 基金项目: |
|
| 摘要点击次数: 2743 |
| 全文下载次数: 1588 |
| 中文摘要: |
| 目的 观察一定剂量的外照射后不同时期加腔内放射治疗的疗效及副作用,以探讨较适当的腔内照射时机。方法 100例食管癌患者随机分2组,A组35Gy外照射后,即开始内外照射同期进行。B组50Gy外照射后开始腔内照射。两组外照射总吸收剂量均为50Gy,采用常规分割照射,1.8～2Gy/次,5次/周。腔内照射5Gy/次,每周1次,共2次。结果 A组的1、3和5年局控率分别为60.2%、39.8%和36.2%,B组的1、3和5年局控率分别为54.1%、32.8%和29.2%;P=0.5118。两组的1、3和5年生存率分别为52.0%、26.0%、21.8%和54.0%、23.4%、16.7%,P=0.8159。A组和B组急性放射性食管炎的发生率分别为70%(35/50)和48%(24/50),P=0.038,但严重的食管炎(Ⅲ级及以上)的发生率相当,均为4%。A组和B组食管瘘的发生率分别为8%(4/50)和10%(5/50)。结论 于35Gy外照射后同期加腔内照射及外照射50Gy结束后即局部补加腔内照射均是可行的。两种治疗方案相比,前者急性放射性食管炎的发生率高于后者,但晚期并发症无增加。 |
| 英文摘要: |
| Objective To investigate the effectiveness and side-effects of booster brachytherapy after different doses of external beam irradiation and to determine the proper time for brachytherapy in esophageal carcinoma. Methods One hundred eligible patients with esophadeal carcinoma were randomized into two groups(group A and group B). In group A, an intracavitary booster brachytherapy was given concomitantly with an external beam irradiation(EBI) when the total dose of EBI reached 35 Gy. While in the group B, the intracavitary booster brachytherapy was given just after EBI reached 50 Gy. The total dose of EBI in both groups was 50 Gy (2 Gy per fraction, 1 time a day for 5 days per week). Five Gy of intracavitary brachytherapy was given once a week for 2 times. EBI was not given during the day of brachytherapy. Results The 1-, 3-, 5-year local control rates were respectively 60.2%, 39.8%, 36.2% in group A and 54.1%, 32.8%, 29.2% in group B (P=0.5118) and the 1-, 3-, 5-year survival rates were respectively 52.0%, 26.0%, 21.8% and 54.0%, 23.4%, 16.7% (P=0.8159). The esophagitis rate in group A and group B was 70% and 48% respectively with P=0.038. But the rate of severe esophagitis was the same in the two groups. The fistula rate was 8% and 10%, respectively. Conclusion Intracavitary booster brachytherapy was feasible either after 35 Gy or 50 Gy of EBI in esophageal carcinoma. A higher morbidity of acute esophagitis was observed in group A than in group B. Both protocols are tolerable. |
| HTML 查看全文 查看/发表评论 下载PDF阅读器 |
| 关闭 |
|
|
|