| 刘雅洁,王树滨,郭一玲,陈佐伟,张英男.烟酰胺和碳合氧增敏89Sr治疗多发性骨转移癌的临床研究[J].中华放射医学与防护杂志,2005,25(6):545-547 |
| 烟酰胺和碳合氧增敏89Sr治疗多发性骨转移癌的临床研究 |
| Clinical study of 89Sr therapy with radiosensitization by nicotinamide and carbogen in multiple bone metastasis of malignant neoplasms |
| 投稿时间：2005-01-04 |
| DOI： |
| 中文关键词: 恶性肿瘤 骨转移 89Sr 烟酰胺 碳合氧 |
| 英文关键词:Malignant neoplasms Bone metastasis 89Sr Nicotinamid Carbogen |
| 基金项目:广东省自然科学基金资助项目(000372) |
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| 中文摘要: |
| 目的 评价烟酰胺和碳合氧(Carbogen)增敏89Sr治疗多发性骨转移癌的作用、骨痛的缓解及毒副反应。方法 97例恶性肿瘤多发性骨转移患者随机分为4组烟酰胺+Carbogen+89Sr治疗组(A组);烟酰胺+89Sr治疗组(B组);Carbogen+89Sr治疗组(C组);89Sr治疗组(D组)。89SrCl2治疗采用1.48～2.22MBq/kg,静脉注射。注射89Sr前1h开始给予烟酰胺,6g/d,分3次口服,连服5d。首次口服烟酰胺后开始吸入Carbogen(95%O2+5%CO2)气体,6L/min,10min,每日1次,连续5d。结果 A组治疗后骨痛的缓解及生活质量较B组、C组及D组有效率高(91.7%、77.3%、76.0%和69.2%),且A组与D组比较差异有统计学意义(P=0.048)。治疗后3个月复发性骨转移癌全身骨显像反应,各组之间差异无统计学意义。各组病人治疗后均有Ⅰ～Ⅱ度骨髓抑制,各组之间差异无统计学意义。结论 烟酰胺+Carbogen+89Sr治疗多发性骨转移癌,对骨痛的缓解及生活质量的改善有更好的疗效,且未增加89Sr的治疗毒性反应。 |
| 英文摘要: |
| Objective To evaluate the curative effect and side effects of 89Sr therapy with radiosensitization by nicotinamide and carbogen in multiple bone metastasis of malignant neoplasms. Methods Ninty-seven patients were divided into 4 groups respectively: group A, 89Sr + nicotinamide + carbogen（24 patients）; group B, 89Sr + nicotinamide（22 patients）; group C, 89Sr + carbogen（25 patients）; group D, 89Sr,（26 patients）. 89SrCl was intravenously injected at a dose of 1.48-2.22 MBq/kg. Nicotinamide was taken orally 1 hour before 89SrCl injection, 6 g/day, tid, d1-d5. Aspiration of carbogen（95%O2+5%CO2） gases,6 L/min,10 minuts, qd,d1-d5. Results The effective rate of pain control and QOL improvement in A group were higher than in groups B, C and D （91.7% VS 77.3%,76.0% and 69.2%,P=0.048 ）. The lesions assessed by SPECT imaging in every group was not significantly different at three months after treatment.Ⅰ to Ⅱ degree toxic effect on bone marrow appeared in every group and there were no significantly inter-group differences. Conclusions Combinative therapy using 89Sr + nicotinamide + carbogen is more effective to treat multiple metastatic bone pain and for improvement of QOL. The side effects are not increased.; |
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