| 杜延荣,陈方,李方,等.药盒法制备99mTc-RBC的人体内稳定性及内照射剂量研究[J].中华放射医学与防护杂志,2005,25(5):456-458.DU Yan-rong,CHEN Fang,LI Fang,et al.Stability and dosimetry of 99mTc-RBC prepared by kit method in healthy volunteers[J].Chin J Radiol Med Prot,2005,25(5):456-458 |
| 药盒法制备99mTc-RBC的人体内稳定性及内照射剂量研究 |
| Stability and dosimetry of 99mTc-RBC prepared by kit method in healthy volunteers |
| 投稿时间：2004-10-18 |
| DOI： |
| 中文关键词: RBC药盒 99mTRBC 人体内稳定性 内照射辐射吸收剂量 |
| 英文关键词:RBC kit 99mT-RBC In vivo stability Absorbed radiation dose |
| 基金项目: |
| 作者 | 单位 | | 杜延荣 | 100730 北京, 中国医学科学院中国协和医科大学, 北京协和医院核医学科 | | 陈方 | 100730 北京, 中国医学科学院中国协和医科大学, 北京协和医院核医学科 | | 李方 | 100730 北京, 中国医学科学院中国协和医科大学, 北京协和医院核医学科 | | 陈黎波 | 100730 北京, 中国医学科学院中国协和医科大学, 北京协和医院核医学科 | | 龙明清 | 100730 北京, 中国医学科学院中国协和医科大学, 北京协和医院核医学科 |
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| 中文摘要: |
| 目的 研究用自制RBC药盒制备的99mTRBC人体内稳定性和内照射辐射吸收剂量。方法 4名健康志愿者,分别取肘静脉血1ml,用自制的RBC药盒进行放射性锝标记,每人注射481～555MBq,给药后5min,1,2.5,4,8和24h进行全身显像,测定99mTRBC在人体内的生物分布;计算各器官在各时间点的放射性占注入量的百分数(%ID);两种方法绘制各脏器时间放射性计数曲线,计算各脏器的滞留时间,用MIRDOSE3.0软件计算出各受照器官的内照射辐射剂量。结果 99mTRBC在人体内较稳定,血池及大血管于给药后5min至8h均可清晰显影;人体内照射辐射吸收剂量估算结果与文献值相近,按一次给药555MBq计算,各器官的吸收剂量均低于50mGy。结论 用本实验室自制RBC药盒制备的99mTRBC体内稳定性好,内照射辐射吸收剂量符合要求。 |
| 英文摘要: |
| Objective To study the in vivo stability of and absorbed radiation dose from 99mT-RBC, prepared using RBC kit made in our laboratory. Methods Four healthy volunteers were studied with 99mT-RBC prepared by kit method. Whole body images were acquired at 5 min, 1, 2.5, 4, 8 and 24 hours after intravenous injection of 481-555 MBq 99mT-RBC. Biodistribution analysis was performed in regions of interest (ROI). The absorbed radiation doses were calculated using the MIRDOSE3.0 analysis program and the time-related activity curves for different organs were used for the residence time calculations. Results 99mT-RBC prepared by kit method was stable in vivo. The quality of blood pool imaging from 5 min to 8 h in healthy volunteers was satisfactory. The absorbed radiation dose was lower than the permissible value. Conclusion 99mT-RBC prepared by kit method is very suitable for clinical application. |
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