| 尉岩,闫晨华,史惠琳,刘艳荣,邱镜莹,江滨,王德炳.骨髓形态学在单核细胞白血病诊断中的作用[J].中华放射医学与防护杂志,2005,25(4):354-356 |
| 骨髓形态学在单核细胞白血病诊断中的作用 |
| Role of cytochemical staining in diagnosis of monocytic leukemia |
| 投稿时间：2005-04-24 |
| DOI： |
| 中文关键词: 急性单核细胞白血病 急性粒-单核细胞白血病 骨髓形态 免疫分型 诊断 细胞遗传学 |
| 英文关键词:Acute monocytic leukemia Acute myelomonocytic leukemia Morphology Immunophenotype Diagnosis Cytogenetics |
| 基金项目: |
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| 中文摘要: |
| 目的 探讨骨髓形态学(包括细胞化学染色)在急性单核细胞白血病(AMLM5)和急性粒单核细胞白血病(AMLM4)形态学、免疫学及细胞遗传学(MIC)分型中的作用。方法 对47例初治AML的骨髓穿刺标本进行形态学、免疫表型和染色体检查,并对检查结果进行分析。结果 47例形态学诊断为AMLM4和AMLM5的患者最终经MIC分型诊断为AMLM525例;AMLM419例(其中AMLM4Eo5例);t(8;21)AML2例;T细胞性急性淋巴细胞白血病(TALL)1例。结论 在AMLM4及AMLM5的MIC分型中,骨髓形态学仍具有重要的的诊断价值,免疫分型和染色体检查与形态学相互依存,有助于进一步提高诊断的准确率。 |
| 英文摘要: |
| Objective To explore the role of cytochemical staining in MIC(morphology,immunology and cytogenetics) typing of acute monocytic leukemia(AML-M5)and acute myelomonocytic leukemia (AML-M4). Methods We analyzed the characteristics of morphology,immunology and cytogenetics in 47 cases of diagnosed AML. Results Eventually,they were diagnosed with MIC.There were 25 cases with AML-M5,19 cases with AML-M4(consisted of 5 cases diagnosed AML-M4Eo),2 cases with acute myeloid leukemia with t(8∶21) and 1 case with T-ALL. Conclusions During MIC typing of AML-M4 and AML-M5, the diagnostic value of morphology remains important, for immunophenotype,cytogenetics and morphology are interdependent. Immunophenotype and cytogenetics are necessary for improvement of the accuracy rate of diagnosis. |
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