| 涂彧,周菊英,王利利.MgSO4对大鼠急性放射性脑损伤后钙超载的抑制作用[J].中华放射医学与防护杂志,2005,25(4):339-341 |
| MgSO4对大鼠急性放射性脑损伤后钙超载的抑制作用 |
| Inhibitory effect of MgSO4 on calcium overload after radiation-induced brain injuries |
| 投稿时间：2004-10-29 |
| DOI： |
| 中文关键词: 硫酸镁 脑 辐射效应 大鼠 |
| 英文关键词:Magnesium sulfate Brain Radiation effects Rats |
| 基金项目:苏州大学优秀青年骨干教师培养人选科研基金项目 |
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| 中文摘要: |
| 目的 探讨硫酸镁对电离辐射诱发的脑组织损伤的脑保护作用。方法 将成熟的SD大鼠60只随机分为空白对照组、实验对照组和硫酸镁实验用药组,用6MeV电子线对实验大鼠进行20Gy全脑单次垂直照射,分别于1、7、14和30d处死、取样,应用等离子直读光谱仪定量分析大鼠脑组织中钙、镁离子含量,用干湿重法测定脑组织含水量,并与空白对照组进行比较。同时对各组大鼠脑组织进行了病理观察。结果 与空白对照组相比,实验对照组大鼠脑水肿明显,脑组织中钙离子含量显著升高(P<0.05),镁离子含量显著下降(P<0.05);与实验对照组相比,硫酸镁实验用药组大鼠脑组织Ca2+变化不大,脑水肿程度较前者轻(P<0.05)。结论 早期使用硫酸镁可抑制辐射引起的脑组织中钙离子的超载,减轻脑组织水肿和损伤的程度。 |
| 英文摘要: |
| Objective To explore the neuroprotective effect of magnesium sulfate(MgSO4) on radiation-induced acute brain injuries. Methods A total of 60 mature Sprague-Dawley rats were randomly divided into 3 groups: blank control group, experimental control group and experimental therapy group. The whole brain of SD rats of experimental control group and experimental therapy group was irradiated to a dose of 20 Gy using 6 MeV electrons. Magnesium sulfate was injected intraperitoneally into the rats of experimental therapy group before and after irradiation for five times. At different time points (24 h, 7 days, 14 days, 30 days after irradiation), the brain tissue was taken. Plasma direct reading spectrography was used to measure the contents of Ca2+,Mg2+ in brain tissue, and the percentage of brain water content was calculated with the wet-dry weight formula. Results Compared with the blank control group, the percentage of brain water and content of Ca2+ in brain of the experimental control group increased markedly (P<0.05) while the level of Mg2+ decreased significantly (P<0.05). However, the percentagees of brain water and content of Ca2+ in brain of the experimental therapy group were significantly lower than those of the experimental control group (P<0.05). Conclusion Magnesium sulfate used in the early stage after irradiation can inhibit the calcium overload in rat brain, and attenuate brain edema and injuries.; |
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