| 张霞,季洪兵,陈忠华,欧阳学农,杨如俊.甘氨双唑钠对肺癌体内外放射增敏作用研究[J].中华放射医学与防护杂志,2005,25(4):316-318 |
| 甘氨双唑钠对肺癌体内外放射增敏作用研究 |
| Lung cancer radiosensitization by CMNa in vitro and in vivo |
| 投稿时间：2005-02-28 |
| DOI： |
| 中文关键词: 甘氨双唑钠 肺癌 γ刀 放射增敏 |
| 英文关键词:CMNa Lung Cancer γ-knife Radio-sensitization |
| 基金项目:国家自然科学基金资助项目(30400524);福建省创新人才专项基金资助项目(2004J065) |
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| 中文摘要: |
| 目的 研究甘氨双唑钠对肺癌细胞株照射敏感性及配合肺癌患者应用γ刀治疗的放射增敏作用。方法 肺癌细胞系NCIH446和NCIH596用60Coγ射线照射,同时用或不用甘氨双唑钠配合,台盼蓝拒染法检测存活细胞存活率;绘制细胞生存曲线;应用γ刀治疗的临床各期肺癌患者,治疗前静脉滴注甘氨双唑钠,同时随机选择单纯γ刀治疗未使用甘氨双唑钠者作为对照。1个疗程结束后6周评价疗效。结果 甘氨双唑钠可以显著增加肺癌细胞株对γ射线的敏感性,提高γ射线对肺癌细胞系的杀伤作用;甘氨双唑钠配合γ刀治疗肺癌可显著增加疗效,两组总有效率(CR+PR)分别为47.22%和37.67%,抑瘤率分别为55.42%和44.15%,差异有统计学意义(P<0.05),且与临床分期及病理类型无关(P>0.05)。结论 甘氨双唑钠对肺癌细胞株及肺癌患者的放射治疗有增敏作用,能显著提高放疗疗效,是一种良好的放射增敏剂。 |
| 英文摘要: |
| Objective To probe into the radiosensitization effect of CMNa on lung tumor cell lines after γ_irradiation combined with γ-knife to treat patients suffering from lung cancer. Methods 1.Cells of small cell lung cancer cell line NCI-H446 and non-small cell lung cancer cell line NCI-H596 irradiated with 60Coγ_rays combined with or without CMNa were counted using trypan blue exclusion methods, and cell survival rate curves were depicted. 2. Patients suffering from lung cancer at different clinical stages were treated using γ-knife combined with or without CMNa, and the curative effect was evaluated 6 weeks after one cycle of treatment. Results CMNa could significantly increase the sensitivity of lung cancer cell lines to γ_irradiation. Curative effect increased significantly by γ-knife treatment combined with CMNa i.e.,the CR+PR rates for these two groups were 47.22% and 37.67% separately(P<0.05), and the tumor inhibition rates were 55.42% and 44.15% separately(P<0.05). These effects were not correlated with clinical stage and pathological type of cancer (P>0.05). Conclusion CMNa could significantly increase the radiation sensitivity of lung cancer cell line cells in vitro and tumors in vivo, therefore,it could be used as a radiosensitization agent in clinical treatment of lung cancer.; |
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