| 乔广宇,王迎选,周定标,汪力.不同剂量照射对猪垂体和靶腺的影响[J].中华放射医学与防护杂志,2005,25(2):137-139 |
| 不同剂量照射对猪垂体和靶腺的影响 |
| The pathological observation of the target tissue and the pituitary target organs after different dose irradiation to the porcine pituitary |
| 投稿时间：2004-03-15 |
| DOI： |
| 中文关键词: 立体定向放射外科 垂体 猪 |
| 英文关键词:Stereotactic radiosurgery Pituitary Porcine |
| 基金项目: |
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| 中文摘要: |
| 目的 研究幼年小型猪垂体不同单次剂量照射的放射反应。方法 X射线一次性照射小型猪垂体,实验分为对照组、5、10、15和20Gy组,观察不同剂量对猪垂体和靶腺器官行组织学影响。结果 20Gy组垂体腺细胞轻度固缩、退变,间质小血管充血、增生;各照射组睾丸萎缩,重量减轻,睾丸间质细胞及精原细胞含量下降,且与剂量相关;15Gy和20Gy组甲状腺滤泡上皮细胞不同程度退变;光镜观察未见肾上腺明显改变。结论 垂体激素分泌细胞有不同的放射敏感性,性腺轴最敏感,甲状腺轴次之,肾上腺轴较拒抗。 |
| 英文摘要: |
| Objective To research the radiaton response of the pituitary to the single dose radiation. Methods The porcine hypophysis was irradiated by 5,10,15 and 20 Gy single doses respectively. 40 weeks after irradiation,all animals were exsanguinated and killed for pathologically examining the pituitrary and the pituitary targe organs. Results Degeneration of the pituitary cells and engorgement of the small vessels were observed in the 20 Gy group.The percenatge and the restorative degeree of the leydig cell and the sperm-producing cell were lower in the irradiated groups than that in the control group,and they showed a negative correlation with the dose.The thyroid tissue showed various degree of degeneration in the 15 and 20 Gy groups.No obvious changes were found about the adrenal tissue under the light microscope after irradiation. Conclusion The pituitary hormone-producing cells have the different radiative sensitivity.The pituitary-gonadal axis is most sensitive,and the pituitary_adrenal axis is resistant. |
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