| 李翊,王海青.卡拉胶寡糖对放射损伤的防护作用[J].中华放射医学与防护杂志,2005,25(2):116-117.LI Yi,WANG Hai-qing.Radioprotective effect of carrageenan-derived oligosaccharides on mice with radiation injury[J].Chin J Radiol Med Prot,2005,25(2):116-117 |
| 卡拉胶寡糖对放射损伤的防护作用 |
| Radioprotective effect of carrageenan-derived oligosaccharides on mice with radiation injury |
| 投稿时间：2004-04-12 |
| DOI： |
| 中文关键词: 卡拉胶寡糖 辐射防护 存活率 NK细胞活性 |
| 英文关键词:Carrageenan-derived oligosaccharide Radioprtoective effect Survival rate NK cytostatic activity |
| 基金项目:山东省攻关计划基金资助项目(031070120) |
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| 中文摘要: |
| 目的 探讨卡拉胶寡糖对受60GyX射线照射小鼠的辐射防护作用。方法 采用6MVX直线加速器一次全身照射BALBc小鼠,3个卡拉胶寡糖组照射前连续14d和照射后继续给药7d。观察小鼠30d存活率、外周血白细胞总数、胸腺指数和脾脏指数、脾脏NK细胞活性和腹腔巨噬细胞吞噬功能。结果 卡拉胶寡糖组小鼠30d存活率比照射对照组提高75%～90%;而且卡拉胶寡糖能加速小鼠外周血白细胞的恢复,明显提高胸腺指数和脾脏指数,激活脾脏NK细胞的杀伤活性,增强巨噬细胞吞噬功能。结论 卡拉胶寡糖对受照射小鼠有明显的辐射防护作用。 |
| 英文摘要: |
| Objective To study the radioprotection effect of the carrageenan-derived oligosaccharides on irradiated mice. Methods The carrageenan-derived oligosaccharides were applied to BALB/c mice daily for successive 14 days before whole-body irradiation with 6.0 Gy X-rays and for 7 days after the irradiation.The 30-day survival rate,counts of peripheral white blood cells,thymus and spleen index,cytostatic activity of NK,and peritoneal macrophage phagocytosis were studied. Results The 30-day survival rate elevated from 75% in the control group to 90% in the oligosaccharides-treated group.The carrageenan-derived oligosaccharides significantly promoted recovery of peripheral white blood cells,markedly increased thymus and spleen index,NK cytostatic activity and peritoneal macrophage phagocytosis. Conclusion The carrageenan-derived oligosaccharides has marked radioprotective effect on irradiated mice. |
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