| 高献书,周志国,乔学英,杨香然,张钧,万钧.食管癌患者每周连续7d常规分割加速放疗的Ⅱ期临床研究[J].中华放射医学与防护杂志,2005,25(1):59-62 |
| 食管癌患者每周连续7d常规分割加速放疗的Ⅱ期临床研究 |
| A preliminary report of 7-day continuous accelerated irradiation in patients with esophageal carcinoma |
| 投稿时间：2004-06-26 |
| DOI： |
| 中文关键词: 食管癌 放射治疗 加速分割 毒性反应 总治疗时间 |
| 英文关键词:Esophageal cancer Radiotherapy Accelerated fractionation Toxicity Overall treatment time |
| 基金项目: |
|
| 摘要点击次数: 2830 |
| 全文下载次数: 1799 |
| 中文摘要: |
| 目的 评价连续7d常规分割加速放射治疗食管癌的毒性反应和近期疗效。方法 57例食管鳞癌患者随机分为2组,连续7d常规分割加速放射治疗组(连续组)29例和后程加速超分割放射治疗组(后超组)28例。连续组治疗方法1次d,2Gy次,7d周,吸收剂量60Gy30次,共30d;后超组前半程为常规分割(5次周,2Gy次),照射至30Gy时改加速超分割(2次d,1.5Gy次,5d周),吸收剂量60Gy,共35次,33～35d。结果 连续组急性放射性食管炎高峰出现的时间较后超组早,食管炎发生的程度较后超组高,但两者差异无统计学意义(P>0.05),Ⅲ级以上急性放射性食管炎发生率连续组与后超组分别为344%和143%,两组差异无统计学意义(P=0.077)。晚期反应连续组与后超组相比没有明显增加,Ⅴ级食管晚期反应发生率连续组和后超组分别为10.3%和7.1%(P>0.05)。连续组和后超组1年总生存率分别为66.14%和64.72%。结论 连续组急性黏膜反应的发生率较高,但是大部分患者能忍受急性反应并完成放射治疗。 |
| 英文摘要: |
| Objective Toxicity of the 7-day continuous accelerated irradiation schedule (CAIR) was evaluated and compared with the late course accelerated hyperfractionation radiotherapy schedule (LCAF) for esophageal carcinoma in a randomized trial. Methods Fifty-seven patients with squamous cell carcinoma of esophagus were randomly enrolled into two groups: 29 to the CAIR group and 28 to the LCAF group. In CAIR group the dose per fraction of 2.0 Gy was given once a day at 24 h intervals and the overall treatment time was 4.2 weeks (30 days). The patients in the LCAF group received conventional fractionation radiotherapy, at 2 Gy/fraction, to a dose of 30 Gy in 15 fractions during 3 weeks, followed by accelerated fractionation radiotherapy, b.i.d., at 1.5 Gy/fraction, with a minimal interval of 6 h between fractions, and the overall treatment time was 5 weeks. The total dose was 60 Gy in both groups. Results More serious acute esophagitis was observed in CAIR group than that in LCAF group, and the incidences of grade Ⅲ esophagitis were 31.0% and 14.3%, respectively. The late effect was not more frequent in CAIR group than in the LCAF group, the incidences of grade Ⅴ esophageal late effect were 10.3% and 7.1%, and the 1-year survival rates were 66.14% and 64.72%,respectively in CAIR group and LCAF group. Conclusion Although the higher incidences of severe acute reactions were observed in CAIR group, the patients could tolerate the effects and complete this treatment. |
| HTML 查看全文 查看/发表评论 下载PDF阅读器 |
| 关闭 |
|
|
|