| 徐慧琴,刘功传,金敖兴.DL型丁胱亚磺酰亚胺对大鼠C6神经胶质瘤细胞谷胱甘肽修饰作用的研究[J].中华放射医学与防护杂志,2005,25(1):47-49 |
| DL型丁胱亚磺酰亚胺对大鼠C6神经胶质瘤细胞谷胱甘肽修饰作用的研究 |
| Study on effect of DL-BSO on GSH content in rat C6 glioma cells |
| 投稿时间：2004-02-28 |
| DOI： |
| 中文关键词: DL型丁胱亚磺酰亚胺 大鼠C6神经胶质瘤细胞 谷胱甘肽 |
| 英文关键词:DL-buthionine sulfoximine Rat C6 glioma cells Glutathione |
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| 中文摘要: |
| 目的 研究巯基修饰剂DL型丁胱亚磺酰亚胺(DLBSO)对大鼠C6神经胶质瘤细胞谷胱甘肽(GSH)含量的修饰作用。方法 利用Tietze还原酶法观察DLBSO对大鼠C6神经胶质瘤细胞GSH的作用。结果 经DL-BSO作用后大鼠C6神经胶质瘤细胞GSH含量逐渐下降,并随时间延长下降速度延缓,GSH最低为对照组的6.08%。结论 DLBSO能降低神经胶质瘤细胞的GSH含量。 |
| 英文摘要: |
| Objective To observe the effect of DL-buthionine sulfoximine (DL-BSO) on GSH content in rat C6 glioma cells. Method Tietze method was used to detect the effect of DL-BSO on GSH content. Results The GSH content in rat C6 glioma cells reduced effectively after DL-BSO treatment, the reduction speed showed down with time,and the lowest value of the GSH content was 6.08% of that of the control. Conclusion DL-BSO can deplete intracellular GSH content in rat C6 glioma cells. |
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