| 丁小凡,李文建,李德杏,陈龙华,郭红云.重离子对小鼠移植性Lewis肺癌分次照射的生物效应[J].中华放射医学与防护杂志,2005,25(1):45-47 |
| 重离子对小鼠移植性Lewis肺癌分次照射的生物效应 |
| Biological effects of fractionated irradiation with heavy-ions on Lewis lung tumour growing in mice |
| 投稿时间：2004-04-24 |
| DOI： |
| 中文关键词: 碳离子 分次照射 Lewis肺癌 |
| 英文关键词:Carbon ions Fractionated irradiation Lewis lung tumour |
| 基金项目:甘肃省科技基金资助项目[(1999)424] |
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| 中文摘要: |
| 目的 研究重离子不同分次照射的生物效应。方法 除对照组外,选择了2个剂量点:低剂量为12Gy,高剂量为24Gy。每个剂量分单次、2和3次照射组,观察Lewis肺癌的肿瘤体积变化、肿瘤生长延迟时间和荷瘤小鼠生存时间。结果 无论高剂量还是低剂量,分3次照射的肿瘤生长延迟和生存时间都显著大于单次和分2次照射。结论 采用分3次照射的肿瘤生物效应优于单次和分2次照射,低剂量又优于高剂量。此研究结果为我国重离子束治疗肿瘤的临床试验提供了实验依据。 |
| 英文摘要: |
| Objective To investigate the biological effects of various fractionated irradiation with heavy-ions on tumour growth delay of Lewis lung tumor and the survival times of mice bearing the tumor. Methods In addition to a control group(no irradiation), a low dose (12 Gy)group and a high dose group (24 Gy) were included in this study. In each dose group, tumour-bearing mice were divided into three sub-groups irradiated respectively with single dose, 2 fractionated-dose and 3 fractionated-dose of carbon-ion beams accelerated by HIRFL in Modern Physics Institute of Chinese Academy of Sciences. Tumour volume was measured with calipers every other 3 days. Results No matter in the low dose group or in the high dose group, the tumour growth delay and the survival times (P<0.05) of 3 fractionated-dose irradiation increased more than those of single dose and 2 fractionated-dose irradiation. Conclusion These results offer the basic data for suggestion of use of 3 fractionated-dose irradiation at low dose in clinical trials of carbon-ion beams. |
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