| 李翊,王海青.卡拉胶寡糖对放射损伤小鼠T细胞功能和亚型的影响[J].中华放射医学与防护杂志,2005,25(1):41-42 |
| 卡拉胶寡糖对放射损伤小鼠T细胞功能和亚型的影响 |
| Effect of carrageenan-derived oligosaccharides on T cell function and subsets in irradiated mice |
| 投稿时间：2004-04-25 |
| DOI： |
| 中文关键词: 卡拉胶寡糖 放射损伤 T细胞功能 CD4+/CD8+ |
| 英文关键词:Carrageenan-derived oligosaccharide Irradiation-induced injury T-cell function CD4+/CD8+ |
| 基金项目:山东省攻关计划基金资助项目(031070120) |
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| 中文摘要: |
| 目的 探讨卡拉胶寡糖对受X射线照射小鼠T细胞功能和亚型的影响。方法 采用直线加速器6MVX射线一次全身照射BALBc小鼠,卡拉胶寡糖组照射前连续14d和照射后继续给药7d。检测小鼠脾脏淋巴细胞增殖反应,胸腺细胞表达CD69 变化,外周血T细胞表达IL-2、IFN-γ和TNF-α变化及CD4+/CD8+比值。结果 卡拉胶寡糖能有效提高脾脏T淋巴细胞的增殖能力,胸腺T细胞表达CD69 显著升高,使受照射小鼠外周血T细胞产生IL2和IFN-γ的能力显著增强,外周血T细胞表达TNF-α的能力降低,并能显著升高外周血T细胞CD4+/CD8+比值。结论 卡拉胶寡糖对放射损伤小鼠的T细胞功能和亚型有明显调节作用。 |
| 英文摘要: |
| Objective To observe the effect of carrageenan-derived oligosaccharides on T cell function and subsets in irradiated mice. Methods The carrageenan-derived oligosaccharides were applied to BALB/c mice for 14 successive days before and 7 days after whole body irradiation with 6.0 Gy X-rays. The transformation response of splenic lymphocyte,the expression of CD69 in thymocytes,IL-2,IFN-γ and TNF-α in T-cells of PBMC,and CD4+/CD8+ ratio of T lymphocytes were evaluated. Results The carrageenan-derived oligosaccharides increased ConA-stimulated transformation of splenic T lymphocytes of mice,characterized by marked up-regulation of CD69 expression in thymic lymphocytes,significantly enhanced the ability of PBMC to produce IL-2 and IFN-γ,decreased the expression of TNF-α in T-cells of PBMC,and over-expressed CD+ 4 in T lymphocytes,followed by increment in CD4+/CD8+ ratio of T lymphocytes. Conclusion Carrageenan-derived oligosaccharides can markedly adjust T cell function and subsets in irradiated mice. |
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