| 王月英,王汝勤,赵忠萍.E838对小鼠辐射防护作用的研究[J].中华放射医学与防护杂志,2005,25(1):39-40 |
| E838对小鼠辐射防护作用的研究 |
| Radiation protective effects of four kind of estrogens on mice |
| 投稿时间：2004-06-28 |
| DOI： |
| 中文关键词: E838 炔雌醇 炔雌三醇 雌三醇 照射 存活率 雌活性 |
| 英文关键词:E838 EE2 EE3 E3 Irradiation Survival rate Estrogen activity |
| 基金项目:天津市自然科学重点基金资助项目(043802411) |
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| 中文摘要: |
| 目的 本研究对比观察E838 、炔雌醇(EE2 )、炔雌三醇(EE3 )、雌三醇(E3 )对照射小鼠30d存活率及E838 、炔雌醇雌活性对比测定。方法 实验分E838 、EE2 、EE3 、E3 、对照共5组,第1批小鼠照射前36h腹腔注射给药1次,对照组腹腔注射茶油,第2批小鼠在照射前3d连续腹腔注射给药、对照组注射茶油,每日1次,经137Csγ射线8.0Gy全身一次性照射后,观察小鼠生存天数。出生18d雌性小鼠腹腔注射0.2ml,连续3d给药后取子宫称重。结果 照射前3d连续注射E838 药物效价最高,存活率提高339%,雌活性低。结论 E838 药物对造血组织有明显的放射防护作用,毒副作用小,能提高机体的防御能力。 |
| 英文摘要: |
| Objective To observe the radioprotective effect of E838 , ethinyl estradiol (EE2 ), ethinyl estriol (EE3 ), estrio (E3 ) on survival rate of KM mice irradiated with 8.0 Gy γ-rays,and compare estrogen activities of E838 and EE2 . Methods Five groups of KM mice were injected intraperi-toneally with E838 ,EE2 ,EE3 ,E3 and tea oil (control group) respectively at 36 h or during 3 succesive days before irradiation. The doses were 25 μg for E838 , EE2 , 100 μg for EE3 and E3 per mouse.Female mice of 18 days old were injected with E838 and EE2 on 3,2 and 1 before irradiation. The radiation dose was 8 Gy 137Cs γ-rays with dose rate 1 Gy/min. Results The 30-day survival rate of mice injected with E838 on 3,2 and 1 before irradiation was the highest,and the averaged survival rate was 33.9% higher than that of the control group. The estrogen activity of E838 was low. Conclusion E838 is an effectively protective drug aganist radiation. |
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