| 吴宁,孙汉英,刘文励,孟凡凯,李春蕊,何莉.放射损伤小鼠骨髓单个核细胞表面bFGFR、Flt-1的表达[J].中华放射医学与防护杂志,2005,25(1):25-26 |
| 放射损伤小鼠骨髓单个核细胞表面bFGFR、Flt-1的表达 |
| Expression of bFGFR,Flt-1 in murine bone marrow mononuclear cells with radiation injury |
| 投稿时间：2004-02-27 |
| DOI： |
| 中文关键词: 辐射 骨髓 bFGFR Flt-1 |
| 英文关键词:Irradiation Bone marrow bFGFR Flt-1 |
| 基金项目:国家自然科学基金资助项目(39870926) |
|
| 摘要点击次数: 2357 |
| 全文下载次数: 1690 |
| 中文摘要: |
| 目的 探讨放射损伤对小鼠骨髓单个核细胞表面bFGFR、Flt-1表达的影响。方法 流式细胞仪检测照射后昆明小鼠骨髓单个核细胞表面bFGFR、Flt-1表达水平的变化。结果 放射损伤后小鼠骨髓单个核细胞表面bFGFR、Flt-1表达水平显著低于正常组(t=233～635,t=414～2061,P<0.01～P<0.05),随时间延长,bFGFR、Flt-1表达逐渐增高,但14d时仍稍低于正常组(t=233～417,P<0.05～P<0.01);骨髓单个核细胞表面bFGFR表达与Flt-1表达呈正相关(r=0.5533,P<0.05)。结论 60Gy60Coγ射线可损伤骨髓单个核细胞表面bFGFR、Flt-1的表达,进一步说明辐射所致骨髓微环境损伤与骨髓组织中bFGF、VEGE表达异常有关。 |
| 英文摘要: |
| Objective To analyse the expressions of bFGFR,Flt-1 in mice bone marrow mononuclear cells(BMMNC) after exposure to γ-radiation. Methods Kunming strain mice irradiated with 6.0 Gy 60Co γ-rays were used to analyse the bFGFR and Flt-1 expression in BMMNC by flow cytometry on days 3,7 and 14 after irradiation. Results Expressions of bFGFR,Flt-1 in BMMNC after irradiation were significantly lower than those in normal BMMNC (t=2.33-6.35 and 4.14-20.61;P<0.05 and P<0.01,respectively). Their expressions were still lower on day 14(t=2.33 and 4.17;P<0.05 and P<0.01,respectively). The expressions of bFGFR,Flt-1 in BMMNC showed direct correlation(r=0.5533,P<0.05). Conclusion γ-radiation inhibits bFGFR,Flt-1 expressions in BMMNC,suggesting that the abnormal expressions of bFGFR,Flt-1 in BMMNC are involved in the injury of hematopoietic microenvironment(HIM) by γ-radiation. |
| HTML 查看全文 查看/发表评论 下载PDF阅读器 |
| 关闭 |
|
|
|