| 周永,糜漫天,杨镇洲.三羟异黄酮对照射小鼠造血系统损伤的防护作用[J].中华放射医学与防护杂志,2005,25(1):21-24 |
| 三羟异黄酮对照射小鼠造血系统损伤的防护作用 |
| Radioprotective effect of genistein on hematopoietic system of mice |
| 投稿时间：2004-04-26 |
| DOI： |
| 中文关键词: 三羟异黄酮 辐射防护 造血系统 骨髓 |
| 英文关键词:Genistein Radioprotection Hematogenesis Bone marrow |
| 基金项目:国家自然科学基金资助项目(30100046) |
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| 中文摘要: |
| 目的 探讨三羟异黄酮(Genistein)对辐射损伤小鼠造血系统的防护作用。方法 6.0Gyγ射线全身照射BALBc雄性小鼠,分4组,照射前24h给予genistein灌胃,观察小鼠照射后30d存活情况及不同时相点有关造血指标的变化,同时HE染色观察骨髓病理学改变。结果 Genistein处理组小鼠骨髓照后损伤较R组轻,外周血WBC、骨髓有核细胞数和CFUS下降幅度小且恢复较快(P<0.05),同时genistein能明显延长辐射损伤小鼠的平均存活天数、提高小鼠30d存活率(P<0.05),以上结果均与已烯雌酚处理组相似,而且genistein对小鼠脾重系数的恢复也有一定的促进作用(P<0.05)。结论 Genistein能降低辐射对小鼠造血系统的损伤,具有一定的辐射保护作用。 |
| 英文摘要: |
| Objective To study the radioprotective effect of genistein on mice hematopoietic system. Methods Adult male BALB/c mice were administered orally with genistein 24 h before exposure to a sublethal dose of 6.0 Gy gamma irradiation.The 30-day survival rate and some indices with relation to hematogenesis were examined after irradiation and pathologic changes of bone marrow were detected by hematotoxylin-eosin staining. Results Bone marrow was damaged slightly, and the numbers of peripheral blood WBC , bone marrow nucleated cells and CFU-S were all significantly higher and restored more rapidly in genistein-treated groups than those in the corresponding irradiated controls(P<0.05). Meanwhile,genistein could also increase the 30-days survival rate and the average survival days of dead mice(P<0.05). All results were similar to those in diethylstilbestrol-treated groups. In addition,genistein could promote recovery of spleen/body weight ratio (P<0.05). Conclusion These observations suggest that genistein has the capability of reducing the damage of hematopoietic system in irradiated mice and has significant protective effect on mice against radiation injury. |
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