中华放射医学与防护杂志

孙银萍,胡国清.放射或放射联合泰素对鼻咽癌细胞p57^kip2蛋白表达的影响[J].中华放射医学与防护杂志,2004,24(5):444-446.SUN Yin-ping,HU Guo-qing.Effect of irradiation or irradiation combined with taxol on expression of antiongene p57^Kip2 in nasopharyngeal carcinoma cells in vitro[J].Chin J Radiol Med Prot,2004,24(5):444-446

放射或放射联合泰素对鼻咽癌细胞p57^kip2蛋白表达的影响

Effect of irradiation or irradiation combined with taxol on expression of antiongene p57^Kip2 in nasopharyngeal carcinoma cells in vitro

投稿时间：2003-11-07

DOI：

中文关键词: 鼻咽癌细胞 p57^kip2蛋白放射敏感性泰素放射增敏剂

英文关键词:Nasopharyngeal carcinoma cell p57^kip2 protein Radiosensitivity Taxol Radio-sensitizer

基金项目:

作者	单位	E-mail
孙银萍	430030 武汉, 华中科技大学同济医学院附属同济医院肿瘤中心	sunyinping@yahoo.com.cn
胡国清	430030 武汉, 华中科技大学同济医学院附属同济医院肿瘤中心

摘要点击次数: 3523

全文下载次数: 2121

中文摘要:

目的研究放射或放射联合泰素对鼻咽癌细胞抑癌基因p57^kip2蛋白表达的影响。方法采用免疫组织化学法和WesternBlot法检测鼻咽癌细胞照射前后p57^kip2蛋白表达情况。结果 p57^kip2蛋白在鼻咽癌细胞中弱阳性表达,单纯照射组和照射联合泰素组可见p57^kip2蛋白在照射后随吸收剂量增加和时间延长其表达均上调(P<0.01),照射联合泰素组的p57^kip2蛋白表达比单纯照射组明显增强(P<0.01)。结论放射或放射联合泰素对鼻咽癌细胞抑癌基因p57^kip2蛋白表达有明显的增强作用。

英文摘要:

Objective To study the effect of irradiation or irradiaton combined with taxol on expression of antioncogene p57^kip2 in nasopharyngeal carcinoma cells. Methods To test the expression of antioncogene p57^kip2 by immunohistochemistry and Western blot before and after irradiation of the cells. Results The expression of p57^kip2 protein was weak in nasopharyngeal carcinoma cells.Both in single irradiation group and in irradiation combined with taxol group,the expression of p57^kip2 protein improved along with increase of dose and time length after irradiation(P<0.01).The expression of p57^kip2 protein was stronger in the irradiation combined with taxol group than in the single irradiation group(P<0.01). Conclusion The up-regulation of expression of p57^kip2 antioncogene may reflect the enhancement of radiosensitivity of the nasopharyngeal carcinoma cells induced by both single irradiation or irradiation combined with taxol.

HTML 查看全文查看/发表评论下载PDF阅读器

关闭