| 李旭东,刘璐,刘志勇,马超,王宇,谢亦山,高宏,蒋佩明,童冠圣,封国生.32P-磷酸铬组织间照射在食管、贲门癌手术中的应用评价[J].中华放射医学与防护杂志,2004,24(5):435-438 |
| 32P-磷酸铬组织间照射在食管、贲门癌手术中的应用评价 |
| Interstitial irradiation using 32P-chromic phosphate during resection of cardio-esophageal carcinoma |
| 投稿时间：2004-01-08 |
| DOI： |
| 中文关键词: 食管癌 贲门癌 淋巴转移 手术疗法 放射疗法 胶体类 磷放射性同位素 |
| 英文关键词:Esophageal carcinoma Cardiac carcinoma Lymphatic metastasis Surgical treatment Radiotherapy Colloids Phosphorus radioisotopes |
| 基金项目:铁道部科研基金资助项目(J1998Z021);江苏省卫生厅科研基金资助项目(H200117) |
|
| 摘要点击次数: 2777 |
| 全文下载次数: 1911 |
| 中文摘要: |
| 目的 研究32P磷酸铬(32P胶体)术中间质给药行组织间照射在食管、贲门癌治疗中的作用。方法 对91例食管、贲门癌临床确诊病例,在剖胸手术中切除病变食管及胃体后,于病灶相应部位及其淋巴引流区域间质组织内多点浸润注射,未能切除病灶者注射于瘤体组织及其淋巴引流区域内,32P胶体剂量为296～370MBq10ml。对照组99例为同期同病种单纯手术病例。观察两组围术期并发症发生情况、淋巴结转移时间、淋巴结转移率及术后1、3和5年生存率。结果 手术+32P胶体组及单纯手术组均无手术死亡,围术期并发症发生率两组差异无显著性(P>0.05)。两组术后淋巴结转移时间、纵隔淋巴转移率、锁骨上淋巴结转移率和腹腔淋巴结转移率差异有显著性(P<0.05)。术中切除肿瘤的手术+32P胶体组术后1、3和5年生存率分别为72.5%、56.4%、42.6%,单纯手术组分别为67.7%、38.1%、25.0%。术后1年生存率两组差异无显著性(P>0.05),术后3及5年生存率两组差异有显著性或非常显著性(P<0.05,P<0.01)。结论 32P胶体间质给药应用于食管、贲门癌手术中,方法简单,使用安全,在控制术后淋巴结转移及提高中远期生存率方面具有良好的临床疗效。 |
| 英文摘要: |
| Objective To explore the effectiveness of 32P-chromic phosphate (32P-colloid) by stromal injection during cardio-esophageal carcinoma resection. Methods To 91 patients with clinically diagnosed cardio-esophageal carcinoma,infiltrative injection of 32P-colloid (296-370 MBq/10 ml) was administer either into the interstitial tissues neighboring to the site of lesion and the region of lymphatic drainage after resection of the tumor or,for those patients whose tumor could not be removed,32P-colloid was injected into the tumor proper and the lymphatic drainage region.The control group included 99 patients with the same diagnosis,who were operated in the same period of time but not injected with 32P-colloid.The peri-operative complication,time and rate of lymphatic metastasis,and the post-operative survival rates at 1-,3-,and 5-year were followed. Results No operative death occurred in both groups.The incidences of peri-operative complication were not different statistically between these two group (P>0.05).The time of lymph node metastasis and the incidences of mediastinal,supraclavicular,and abdominal lymph node metastasis were all statistically different between these two groups (P<0.05).The 1-,3-,and 5-year survival rates were 72.5%,56.4%,and 42.6%,respectively,in the injection group,and were 67.7%,38.1%,and 25.0% in the control group.The 1-year survival rates were not different statistically (P>0.05) between these two groups,while the 3- and 5-year rates were significantly diffeent (P<0.05,P<0.01). Conclusion Stromal medication of 32P-colloid during cardio-esophageal carcinoma resection is a simple and safe procedure in controlling the post-operative lymphatic metastasis and has very fair clinical effectiveness in improving intermediate and late survival rates. |
| HTML 查看全文 查看/发表评论 下载PDF阅读器 |
| 关闭 |
|
|
|