| 朱咏梅,钟进义.海生多糖肽对亚急性辐射损伤小鼠的防护作用[J].中华放射医学与防护杂志,2004,24(5):419-420 |
| 海生多糖肽对亚急性辐射损伤小鼠的防护作用 |
| The protective effect of Hpp against sub-acute radiation damage |
| 投稿时间：2003-12-10 |
| DOI： |
| 中文关键词: 海洋生物 辐射损伤 超氧化物歧化酶 半胱氨酸蛋白酶-3 |
| 英文关键词:Marine biology Radiation damage SOD Caspase-3 |
| 基金项目:青岛市科学基金资助项目(022KJhh72) |
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| 中文摘要: |
| 目的 研究海生多糖肽对小鼠亚急性辐射损伤的防护作用。方法 给小鼠饲以海生多糖肽制剂,用60Coγ射线进行全身性亚急性照射,检测外周血白细胞、脾淋巴细胞转化率、红细胞超氧化物歧化酶、丙二醛和过氧化酶含量、精子畸形率、睾丸精母细胞染色体畸变率和肝细胞半胱氨酸蛋白酶3等指标。结果 海生多糖肽高、低剂量组小鼠的血白细胞数量、脾淋巴细胞转化率、红细胞超氧化物歧化酶值和过氧化酶值均高于照射对照组,红细胞丙二醛值、精子畸形率、睾丸精母细胞染色体畸变率和肝细胞半胱氨酸蛋白酶3阳性表达率则低于照射对照组,差异有显著性。结论 海生多糖肽对亚急性辐射损伤有良好的防护作用。 |
| 英文摘要: |
| Objective To study the protective effect of Hpp against sub-acute radiation damage. Methods Hpp was administered through foods to mice for four weeks,then the mice were exposed to whole-body 60Coγ-rays with 0.125 Gy daily from Monday to Friday for another four weeks. Eight indices including leucocyte count,DNA damage of the spleen cells and the expression levels of SOD、MDA and CAT of erythrocyte,abnormal sperm number, chromosome aberration rate and expression level of hepatocyte caspase-3 were measured on the next day after the last exposure. Results In the two doses of Hpp-treated groups,the amount of leucocyte,DNA content of the spleen cells,SOD and CAT of erythrocyte were higher,while chromosome aberration rate and the hepatic cells caspase-3 in pancreatic cells were lower than those in the positive control group with significant dose-effect relationships. Conclusion Hpp has a significant protective effect against sub-acute radiation damage. |
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