中华放射医学与防护杂志

姜德福,程光惠,马颖哲.肿瘤细胞标志物与乳腺癌预后的相关性研究[J].中华放射医学与防护杂志,2004,24(4):358-360

肿瘤细胞标志物与乳腺癌预后的相关性研究

Relationship between prognosis of breast cancer and expressions of C-erbB-2,PCNA,Bcl-2,P53 and nm23-H₁ protein

投稿时间：2004-01-08

DOI：

英文关键词:Breast cancer Immunohistochemistry Prognostic factors

基金项目:

作者	单位
姜德福	Department of Radiation Oncology, Second Hospital of Jilin University, Changchun 130021, China
程光惠	Department of Radiation Oncology, Second Hospital of Jilin University, Changchun 130021, China
马颖哲

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中文摘要:

目的探讨原癌基因C-erbB-2蛋白、增殖细胞核抗原(PCNA)、凋亡抑制基因(Bcl-2)、p53基因和转移抑制基因(nm23-H₁)在乳腺癌患者接受简化根治术后几项指标同时检测对乳腺癌预后的指导作用。方法对接受相同治疗方案(改良根治术及术后放、化疗)的61例乳腺癌患者的术后石蜡切片标本进行免疫组织化学染色,检测C-erbB-2、PCNA、Bcl-2、P53及nm23-H₁蛋白表达,并随访观察5和8年生存率。结果不同的肿瘤大小、病理分级、淋巴结转移数,患者生存率差异有显著性(P<0.05)。雌激素受体(ER)、孕激素受体(PR)、C-erbB-2、PCNA、Bcl-2、P53、nm23-H₁蛋白阳性及阴性表达组5和8年生存率差异均有显著性(P<0.05)。老年组和青壮年组生存率差异无显著性。结论除传统的预后因素外,肿瘤细胞标志物(C-erbB-2、PCNA、Bcl-2、p53、nm23-H₁)均可作为判断乳腺癌预后的参考指标。

英文摘要:

Objective To examine the expressions of C-erbB-2, PCNA, Bcl-2, P53 and nm23-H₁ protein after modified radical mastectomy, and evaluate the relationship between their expressions and prognosis. Methods A total of 61 cases with breast cancer received the same treatment and their postoperative paraffin-embedded specimens were used for immunohistochemical study to examine the expressions of ER, PR, C-erbB-2, PCNA, Bcl-2, P53, nm23-H₁ protein. The 5, 8-year survival rates were observed by fllow-up. Results The 5 and 8 year survival rates were statisticly different between the patients with different tumor size, histological grading, number of cancer metastasized lymph nodes ( P <0.05).They were also statisticlly different between the patients with positive and negative expressions of ER, PR, C-erbB-2, and Bcl-2, PCNA, P53 and nm23-H₁ protein(P <0.05), but they were negatively correlated with patients'age. Conclusion C-erbB-2, Bcl-2, PCNA, p53 and nm23-H₁ gene can all become the independent prognostic factors of breast cancer.

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