| 聂常富,郭志华,王建国,等.肝动脉化疗栓塞对肝癌患者外周血AFP mRNA表达水平的影响[J].中华放射医学与防护杂志,2004,24(4):356-358.NIE Chang-fu,GUO Zhi-hua,WANG Jian-guo,et al.Evaluating the effect of transcatheter arterial chemoembolization on AFP mRNA in peripheral blood of hepatocellular carcinoma patients[J].Chin J Radiol Med Prot,2004,24(4):356-358 |
| 肝动脉化疗栓塞对肝癌患者外周血AFP mRNA表达水平的影响 |
| Evaluating the effect of transcatheter arterial chemoembolization on AFP mRNA in peripheral blood of hepatocellular carcinoma patients |
| 投稿时间：2004-01-12 |
| DOI： |
| 中文关键词: 肝动脉化疗栓塞 肝肿瘤 AFPmRNA 实时RT-PCR |
| 英文关键词:Transcatheter arterial chemoembolization Liver neoplasm AFP mRNA Real time RT-PCR |
| 基金项目:河南省教育厅自然科学基金资助项目(20003320146) |
| 作者 | 单位 | | 聂常富 | The First Affiliated Hospital of Xinxiang Medical College, Weihui 453100, China | | 郭志华 | The First Affiliated Hospital of Xinxiang Medical College, Weihui 453100, China | | 王建国 | The First Affiliated Hospital of Xinxiang Medical College, Weihui 453100, China | | 荆晓岳 | The First Affiliated Hospital of Xinxiang Medical College, Weihui 453100, China | | 李荣 | The First Affiliated Hospital of Xinxiang Medical College, Weihui 453100, China | | 孔凡明 | The First Affiliated Hospital of Xinxiang Medical College, Weihui 453100, China | | 何蕴韶 | |
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| 中文摘要: |
| 目的 探讨肝动脉化疗栓塞对肝癌患者对外周血AFPmRNA表达水平的影响。方法 采用实时RTPCR技术,定量检测24例肝细胞癌患者肝动脉化疗栓塞前后外周血AFPmRNA的表达水平。结果 肝癌患者肝动脉化疗栓塞前外周血AFPmRNA平均表达水平为(133074.6±27163..7)拷贝μgRNA,肝动脉化疗栓塞后24h、1月、2月平均表达水平分别为(2076.0±423.8)、(1774.5±362.2)和(23650.4±4827.6)拷贝μgRNA。结论 肝动脉化疗栓塞可显著降低肝癌患者外周血AFPmRNA表达水平,AFPmRNA可作为评估肝动脉化疗栓塞效果的一个重要指标。 |
| 英文摘要: |
| Objective To evaluate the effect of transcatheter arterial chemoembolization (TACE)on AFP mRNA in peripheral blood of patients with hepatocellular carcinoma(HCC). Methods Real time RT-PCR was used to detect AFP mRNA expression in peripheral blood of 24 patients with HCC before and after TACE. Results The expression level of AFP mRNA in peripheral blood of the 24 HCC patients averaged (133 074.6± 27 163.7) copies/μgRNA before TACE treatment and(2076.0±423.8)copies/μgRNA, (1774.5±362.2)copies/μgRNA; (23 650.4± 4827.6)copies/μgRNA at 24 hours, 1 month and 2 months after TACE. Conclusion The expression of AFP mRNA is significantly reduced after TACE and it can be used as a marker for evaluating the treatment efficacy for hepatocellular carcinoma. |
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