| 陈英,葛世丽,骆亿生,等.上海“6.25”辐射事故受照射者12年后染色体畸变随访观察[J].中华放射医学与防护杂志,2004,24(4):350-352.CHEN Ying,GE Shi-li,LUO Yi-sheng,et al.A follow-up study of chromosome aberrations 12 years after exposure to a radiation accident in Shanghai[J].Chin J Radiol Med Prot,2004,24(4):350-352 |
| 上海“6.25”辐射事故受照射者12年后染色体畸变随访观察 |
| A follow-up study of chromosome aberrations 12 years after exposure to a radiation accident in Shanghai |
| 投稿时间：2003-11-25 |
| DOI： |
| 中文关键词: 染色体畸变 易位 辐射远后效应 |
| 英文关键词:Chromosome aberrations Translocations Late effects of radiation |
| 基金项目: |
| 作者 | 单位 | | 陈英 | Beijing Institute of Radiation Medicine, Beijing 100850, China | | 葛世丽 | Beijing Institute of Radiation Medicine, Beijing 100850, China | | 骆亿生 | Beijing Institute of Radiation Medicine, Beijing 100850, China | | 刘秀林 | Beijing Institute of Radiation Medicine, Beijing 100850, China | | 金璀珍 | Beijing Institute of Radiation Medicine, Beijing 100850, China |
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| 中文摘要: |
| 目的 对上海“625”5名60Co源事故受照射者12年后的染色体畸变进行追踪观察,为辐射远后效应评价提供依据。方法 常规染色体畸变分析、G显带自动核型分析和1号全染色体探针标记FISH方法,检测非稳定性畸变(Cu)和稳定性畸变(Cs),并与照射后10年期的结果进行比较。结果 Cu畸变已基本丢失,残存的畸变以易位为主;Cs畸变与复杂易位均与受照射剂量和受照射年龄相关,并随照射后时间推移缓慢下降。结论 Cs畸变是评价辐射远后效应的较好指标,但需考虑年龄和时间对畸变造成的影响。 |
| 英文摘要: |
| Objective A follow-up study of chromosome aberrations in 5 victims accidentally exposed to 60 Co-γ-rays 12 years ago was performed to give assessments of the late effect of radiation. Methods Conventional chromosome aberration, G-banding automatic karyotype analysis and WCP 1 FISH technique were used simultaneously. Results Unstable aberrations had been almost lost. Stable aberrations such as reciprocal translocations were observed predominately. The results of karyotype analysis and FISH were very approximate and contributed to the dose-response relationship. Conclusion Stable aberrations are fairly proper for assessment of the late effect of radiation although age and time factors should be considered. |
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