| 郑辉,甄荣,牛惠生,李怀芬.45Ca标记复合钙化合物示踪钙生物动力学观察[J].中华放射医学与防护杂志,2004,24(4):336-338 |
| 45Ca标记复合钙化合物示踪钙生物动力学观察 |
| Radioisotope 45Ca labeling four calcium chemical compounds and tracing calcium bioavailability |
| 投稿时间：2004-04-24 |
| DOI： |
| 中文关键词: 放射性核45Ca 放射性标记 生物利用度 葡萄糖酸钙 柠檬酸钙 碳酸钙 L-苏糖酸钙 |
| 英文关键词:Radioisotope 45Ca Radiolabeling Bioavailability Calcium gluconate Calcium citrinate Calcium carbonate Calcium L-threonate |
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| 中文摘要: |
| 目的 用放射性核素45Ca标记4种钙制剂化合物,并观察和示踪其生物利用度。方法 用45Ca标记葡萄糖酸钙、柠檬酸钙、碳酸钙和L苏糖酸钙,测定大鼠心、肝、脾、肾、脑、胃、肠、血液、粪便和尿中钙离子吸收含量和生物利用度。结果 ①45Ca标记的钙制剂具有较高的放射性活度、较稳定的组织标准曲线和回收率。②示踪4种化合物生物利用度变化显示,有机钙化合物较无机钙化合物更利于组织的吸收。结论 45Ca标记钙制剂生物示踪方法具有灵敏、客观、准确和稳定的特点。 |
| 英文摘要: |
| Objective To build up a new method of the radioisotope 45 Ca labeling four calcium chemical compounds, observe and tracing bioavailability change of calcium labeled with radioisotope 45 Ca. Methods The calcium gluconate(Ca-Glu), calcium citrinate(Ca-Cit), calcium carbonatte(Ca-Car) and calcium L-threonate(Ca-Thr)were labeled by radioisotope 45 Ca. Four calcium chemical compounds of 45 Ca labeling were used of calcium content 200 mg/kg in the rats and measure the absorption content and bioavailability of calcium in tissue of heart, lever spleen, stomach, kidney, brain, intestine, whole blood, urine, faeces. Results ① Radioisotope 45 Ca labeling calcium chemical compound has high radio intensity, more steady standard curve and recover rate. ② The absorption of organic calcium chemical compounds is higher than the inorganic calcium chemical compound in the study of calcium bioavailability. Conclusion The method of tracing with radioisotope45 Ca labeling calcium chemical compounds has the characteristic of the sensitive, objective, accurate and steady in the study of calcium bioavailability. |
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