| 黎福祥,陈龙,董永英,黄江琼,唐东平,朱波,魏党,唐凯,谢莉萍,陈铭忠.低剂量γ射线全身照射对猴免疫功能的影响[J].中华放射医学与防护杂志,2004,24(4):330-332 |
| 低剂量γ射线全身照射对猴免疫功能的影响 |
| The influence of low-dose total body γ-irradiation on immune function of monkey |
| 投稿时间：2003-09-29 |
| DOI： |
| 中文关键词: 低剂量辐射 全身照射 免疫功能 |
| 英文关键词:Low-dose irradiation Whole body irradiation Immune function |
| 基金项目:广西壮族自治区卫生厅基金资助项目(9612) |
| 作者 | 单位 | | 黎福祥 | Affiliated Cancer Hospital of Guangxi Medical University, Nanning 530021, China | | 陈龙 | Affiliated Cancer Hospital of Guangxi Medical University, Nanning 530021, China | | 董永英 | Affiliated Cancer Hospital of Guangxi Medical University, Nanning 530021, China | | 黄江琼 | Affiliated Cancer Hospital of Guangxi Medical University, Nanning 530021, China | | 唐东平 | Affiliated Cancer Hospital of Guangxi Medical University, Nanning 530021, China | | 朱波 | Affiliated Cancer Hospital of Guangxi Medical University, Nanning 530021, China | | 魏党 | Affiliated Cancer Hospital of Guangxi Medical University, Nanning 530021, China | | 唐凯 | Affiliated Cancer Hospital of Guangxi Medical University, Nanning 530021, China | | 谢莉萍 | | | 陈铭忠 | Affiliated Cancer Hospital of Guangxi Medical University, Nanning 530021, China |
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| 中文摘要: |
| 目的 探索大动物低剂量全身照射的适宜剂量,以便评价低剂量全身照射应用于临床的可能性。方法 食蟹猴32只随机分为4组,用γ射线(吸收剂量率为0.175mGymin)分别照射0、30、50和75mGy。分别在环磷酰胺处理前、后,亦即照射前和照射后1、2、8、33和50周检测淋巴细胞亚群、免疫球蛋白及自然肿瘤红细胞花环试验(NTERT)。结果 结果显示白细胞释放细胞因子尤其是CD16参与免疫调控,出现时间剂量的反应;体液免疫中以IgA升高为特征,照射后第8周50和75mGy2个剂量组与对照组相比差异有显著性(P<0.05);NTERT结果显示,在照射后第2周,第1、2、3组分别与第4组相比差异有显著性(P<0.05),但第1组分别与第2、3组相比差异无显著性。结论 γ射线单次低剂量全身照射对免疫功能低下模型的食蟹猴红、白细胞免疫功能有增强其免疫功能的作用。 |
| 英文摘要: |
| Objective To investigate appropriate the dosage of low-dose total body irradiation(TBI) on large animals in order to evaluate the possibility of clinical therapy. Methods A total of 32 cynomolgus were randomized into four groups which were irradiated with 0, 30, 50 and 75 mGy γ-rays respectively, at the dose rate of 0.175 mGy/min to observe their lymphocyte sub-populations, immunoglobulin and the results of natural tumor erythrocyte rosette test(NTERT) before and after receiving cyclophosphamide(CP), namely before and 1, 2, 8, 33 and 50 weeks after irradiation. Results The results indicated that leucocyte release factors, especially CD_ 16 (NK cell); took part in immune regulation and presented a time-dose response. Increase of IgA of the humoral immunity is characteristic, for significant differences were seen between the control group and 75 mGy, 50 mGy groups after 8 weeks' irradiation. Meanwhile, there were significant differences in NTERT result of number 1, 2 and 3 groups as compared with that of number 4 group after 2 weeks' irradiation, but there was no difference between number 1 group and number 2, 3 groups. Conclusion These observation suggest that TBI with low-dose γ-rays can increase erythrocyte and leucocyte function in the reduced immune function model of cynomolgus, and the present observation might provide a theoretic basis for low dose TBI clinical therapy. |
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