中华放射医学与防护杂志

黄培林,童冠圣,刘璐,等.³²P胶体局部给药防治H22移植瘤淋巴道转移的实验研究[J].中华放射医学与防护杂志,2004,24(4):324-327.HUANG Pei-lin,TONG Guan-sheng,LIU Lu,et al.An experimental study on effect of ³²P colloid on lymphatic metastasis of transplanted H22 hepatoma in mices[J].Chin J Radiol Med Prot,2004,24(4):324-327

³²P胶体局部给药防治H22移植瘤淋巴道转移的实验研究

An experimental study on effect of ³²P colloid on lymphatic metastasis of transplanted H22 hepatoma in mices

投稿时间：2004-01-08

DOI：

中文关键词: 32P磷酸铬胶体小鼠 H22腹水型肝癌淋巴道转移体内分布

英文关键词:Chromic ³²P phosphate colloid Mouse Ascitic hepatoma Lymph metastasis Biodistribution

基金项目:江苏省社会发展基金资助项目(BS2000062);铁道部医学科研基金资助项目

作者	单位	E-mail
黄培林	Institute of Nuclear Medicine Research, Southeast University, Nanjing 210009, China	hpl@sen.edu.cn
童冠圣
刘璐	Institute of Nuclear Medicine Research, Southeast University, Nanjing 210009, China
黄鹰	Institute of Nuclear Medicine Research, Southeast University, Nanjing 210009, China
张丽达

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中文摘要:

目的探讨不同剂量的³²P胶体局部注射对小鼠H22移植瘤和区域淋巴结转移灶的治疗作用。方法应用小鼠H22腹水型肝癌淋巴道转移模型,通过肿瘤组织局部给药,观察³²P胶体在模型小鼠移植瘤、区域淋巴结及全身各器官、组织内的分布。结果 ³²P胶体局部给药后主要聚集在瘤体注射局部和区域淋巴结内,而在肝、脾、肺等脏器分布的活度较低。区域淋巴结聚集的活度随给药剂量增高而递增。治疗早期瘤体和窝淋巴结转移灶呈现局灶性坏死。后期移植瘤和区域淋巴结转移灶的瘤组织呈现出血、坏死。结论 ³²P胶体瘤体给药可在局部富集,并可经淋巴道转运、聚集于区域淋巴结,对肿瘤组织和邻近的淋巴结转移灶具有明显的杀伤作用。

英文摘要:

Objective To study the anticancer effects and biodistribution of chromic ³² P phosphate colloid in mice with lymphatic metastasis of hepatoma after intratumoral injection. Methods Forty-eight Km mice with H22 ascites hepatoma were injected with ³² P colloid intratumorally.The distribution of ³² P in regional lymph nodes and other organs was observed dynamically, and its anticancer effectiveness was investigated in the tumor and regional lymph nodes. Results ³² P mainly remained in the tumor and regional lymph nodes, while the of ³² P organs, such as liver, spleen, lung, only retained a mild activity. By histopathologic observation, neoplamic focis could be found in pad, right popliteal lymph node and groin lymph node, and necrosis was seen in the tumor and its metastatic foci in right popliteal lymph node. On day 17 after ³² P treatment, the transplanted tumor focis necrosed thoroughly, and normal structure of regional lymph nodes disappeared, which was replaced by necrotic tissue and hemorrhage. Conclusion The intratumoral administration of chromic [ ³² P] colloid could be used for treatment of the primary tumor, and lymphatic metastatic focus as well, in order to produce obvious anticancer effects.

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