| 叶江枫,戚好文,范风云,等.氟伐他汀防治放射性肺损伤的病理形态学研究[J].中华放射医学与防护杂志,2004,24(4):321-324.YE Jiang-feng,QI Hao-wen,FAN Feng-yun,et al.Pathomorphologic observation on treatment of radiation-induced lung damage in rats with fluvastatin[J].Chin J Radiol Med Prot,2004,24(4):321-324 |
| 氟伐他汀防治放射性肺损伤的病理形态学研究 |
| Pathomorphologic observation on treatment of radiation-induced lung damage in rats with fluvastatin |
| 投稿时间：2004-01-08 |
| DOI： |
| 中文关键词: 放射性肺损伤 氟伐他汀 病理形态学 |
| 英文关键词:Radiation-induced lung injury Fluvastatin Pathomorphology |
| 基金项目:第四军医大学西京医院高新技术项目(200120) |
| 作者 | 单位 | | 叶江枫 | Department of Respirator Medicine, Xijing Hospital, The Fourth Military Medical University, Xi'an 710033, China | | 戚好文 | Department of Respirator Medicine, Xijing Hospital, The Fourth Military Medical University, Xi'an 710033, China | | 范风云 | | | 蒙育林 | | | 赵峰 | Department of Respirator Medicine, Xijing Hospital, The Fourth Military Medical University, Xi'an 710033, China | | 石梅 | | | 赵一岭 | |
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| 中文摘要: |
| 目的 探讨氟伐他汀(fluvastatin,Flu)防治放射性肺损伤的效果。方法 雌性SD大鼠随机分为正常对照组、单纯照射组和氟伐他汀防治组。防治组于照射前1周Flu20mg·kg-1·d-1灌胃,对照组灌服等量生理盐水。直线加速器全胸部照射,照射后5、15、30及60d活杀,取肺组织做病理检查、透射电镜、图像定量分析。结果 照射后30及60d肺炎加重(P<0.01),胶原纤维明显增多,肥大细胞增多。电镜显示Ⅱ型细胞线粒体、毛细血管内皮细胞肿胀,防治组炎症减轻(P<0.01),胶原纤维、肥大细胞减少,Ⅱ型细胞线粒体、内皮细胞损伤明显好转。结论 氟伐他汀能减轻放射性肺损伤炎症反应,减少胶原纤维增殖,有效防治放射性肺损伤。 |
| 英文摘要: |
| Objective To inquire into the means of preventing lung damage induced by thoracic irradiation. Methods SD rats were divided randomly into 3 groups: normal control, irradiated control (Group IC) and irradiated and fluvastatin (Flu)-treated group (Group F). The later two groups of rats were irradiated with X-rays at a dose of 20 Gy thoracically. Beginning from the seventh day before irradiation the rats in the Group F were treated with Flu at a dose of 20 mg per day by garaging until the end of the experiment. Animals from each group were sacrificed on days 5, 15, 30, 60 respectively after irradiation. Sections of lung were examined with light microscopy, electron microscopy and morphometry. Results The rats in the Group IC suffered from typical radiation pneumonitis (P <0.01). Electron microscopy indicated type Ⅱpneumonocytes and capillary endothelial cells were injured in rats of Group IC on days 30, 60. There were increase of collagen and a great quantity of mast cells in irradiated control rats. In rats of the Group F there was slight reaction in the lung. Conclusion Fluvastatin could reduce radiation pneumonitis and inhibit increase of collagen. The treatment and prevention of radiation-induced lung injury in rats with fluvastatin is effective. |
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