| 周美娟,郑莉,丁振华.高温环境对受照射后小鼠生存及外周血淋巴细胞的影响[J].中华放射医学与防护杂志,2004,24(3):273-274 |
| 高温环境对受照射后小鼠生存及外周血淋巴细胞的影响 |
| The effect of natural hot environment on survival and peripheral blood lymphocytes in γ-irradiated mice |
| 投稿时间：2003-05-24 |
| DOI： |
| 中文关键词: γ射线 高温环境 存活时间 淋巴细胞 |
| 英文关键词:γ-ray Hot environment Survival time Lymphocyte |
| 基金项目:军队“十五”医教卫生基金资助项目(01MA127); 第一军医大学留学回国人员启动基金(2003001); 第一军医大学军事医学直接立项管理项目(2002009) |
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| 中文摘要: |
| 目的 研究自然高温环境下, 受γ射线照射小鼠生存的变化及外周血淋巴细胞的改变。方法 实验动物分为室温组和不同时间的自然高温环境组, 分别接受6.5,9.0Gy的γ射线照射和相应的高温作用后, 观察30 d内小鼠的死亡情况以及外周血淋巴细胞变化的规律。结果 65Gy照射的小鼠, 高温9 h和全自然环境组的生存时间与室温组差异有显着性, 9,0Gy照射的小鼠, 高温6,9 h、全自然环境组的生存时间和室温组差异有显着性;室温组小鼠外周血淋巴细胞的下降速度低于各高温组且外周血淋巴细胞存在顿挫回升, 而各高温组无。结论 高温环境, 受照射小鼠的生存指标明显下降;加重照射后早期外周血淋巴细胞下降。 |
| 英文摘要: |
| Objective To study the effect of natural hot environment(NHE) on survival and peripheral blood lymphocytes in γ irradiated in mice. Methods After γ irradiation at the dosage of 6.5 or 9.0 Gy,the mice were exposed to NHE for 0,3,6,9 h or 30 days.After exposure to NHE,mice of the 6 h and 9 h groups. were then bred at room temperature.The survival and peripheral blood lymphocyteds were observed for 30 days. Results There were obvious differences in survival time between the groups that were exposed to NHE for 9 h and 30 d and that of the 0 h group,the mice of these three groups having been irradiated with 6.5 Gy.For 9.0 Gy-irradiated mice,the survival times of the 6,9 h and 30 d groups were all significantly shorter than that of the 0 h group.The descending rate of peripheral blood lymphocytes in 0 h group is smaller than that of all NHE groups There was no lymphocyte fluctuate resuscitation in all NHE groups as seen in the 0 h group. Conclusion There is a significant decrease of survival indexes and a faster descending rate of peripheral blood lymphocytes in mice exposed to after γ irradiation. |
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