| 强永刚,廖永华.(60)Co γ射线对大鼠肺β肾上腺素能受体再生成的抑调作用研究[J].中华放射医学与防护杂志,2004,24(3):237-239 |
| (60)Co γ射线对大鼠肺β肾上腺素能受体再生成的抑调作用研究 |
| Effects of restrain and regulation on production of β-adrenergic receptors in lung of Sprague-Dawley rats by 60Co γ-ray irradiation |
| 投稿时间：2003-05-14 |
| DOI： |
| 中文关键词: γ射线 受体再生成 抑调作用 |
| 英文关键词:γ-ray irradiation Receptor production Restrain and regulation |
| 基金项目:广东省医药卫生科研基金资助项目(A2001482) |
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| 中文摘要: |
| 目的 研究20Gyγ射线对大鼠肺β肾上腺素能受体再生成的抑调作用。方法 采用受体的放射配体分析法, BAAM不可逆阻断β受体做对照组, 定量观察不同时相两组大鼠β受体再生成Bmax变化。结果 β受体对辐射敏感, 照后第20天受体降到最低值, 此后受体开始逐渐恢复, 但再生成速率明显变慢, Pr为(036±003)×109结合位点/mg蛋白h[对照组为(820±1.47)×109,受体再生成的半更新时间比对照组晚10.9d.结论 20Gyγ射线明显抑制β受体再生成, 使受体再生成速率变慢, 受体半更新时间延长。 |
| 英文摘要: |
| Objective To study the restrain and regulation on production of β-adrenergic receptors in Sprague-Dawley rat lung by 20 Gy γ-ray irradiation. Methods To determine production of β-adrenergic receptors(Bmax ) after irradiation and BAAM irreversible blockade by radioligand binding assay of receptors. Results β-adrenergic receptors were sensitive to γ-rays,and the sensitivity level declined to the lowest on day 20 after radiation,then the receptors were recovered gradually.But the receptor production rate(Pr) was slower,i.e.,Pr was (0.36±0.03)×109 sitesmg proteinh [control groups,(8.20±1.47)×109].The half-time of update(T1/2 )was put off for 10.9 days as compared to BAAM group. Conclusion Production of receptors can be restrained by 20 Gy γ-ray irradiation,resulting in lower receptor production rate,and longer half-time of update(T1/2 ). |
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