| 吴宁,孙汉英,刘文励,孟凡凯,李春蕊,余源.放射损伤小鼠骨髓组织中bFGF、VEGF的表达[J].中华放射医学与防护杂志,2004,24(3):210-221 |
| 放射损伤小鼠骨髓组织中bFGF、VEGF的表达 |
| Expression of bFGF,VEGF in bone marrow of mice with radiation injury |
| 投稿时间：2003-07-28 |
| DOI： |
| 中文关键词: 放射损伤 骨髓组织 碱性成纤维细胞生长因子 血管内皮生长因子 |
| 英文关键词:Irradiation Bone marrow bFGF VEGF |
| 基金项目:国家自然科学基金资助项目(39870926) |
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| 中文摘要: |
| 目的 探讨放射损伤对小鼠骨髓组织中bFGF、VEGF表达的影响。方法 采用免疫组织化学SABC法, 检测昆明小鼠经6.0Gy60Coγ射线一次性全身均匀照射后不同时间骨髓组织中bFGF、VEGF表达水平的变化。结果 放射损伤后, 小鼠骨髓组织中bFGF、VEGF表达水平显着低于正常组(P<0.01),随时间延长, 骨髓组织中bFGF、VEGF表达有所恢复, 但14d时仍未恢复正常;骨髓组织中bFGF表达与VEGF表达呈正相关(r=0.824,P<0.01).结论 辐射所致骨髓微环境损伤与骨髓组织中bFGF、VEGF表达异常有关。 |
| 英文摘要: |
| Objective To analyze the expression of bFGF,VEGF in mice bone marrow after exposure to γ-radiation. Methods Kunming strain mice irradiated with 6.0 Gy 60Co γ-rays were used to analyze the bFGF and VEGF expression in bone marrow on days 3,7,14 after irradiation by immunohistochemistry. Results Expressions of bFGF,VEGF in bone marrow of the irradiation group were significantly lower than those of the normal group( P <0.01),and were still lower 14 days after irradiation( P<0.05 or P <0.01).But the expressions of bFGF and VEGF in bone marrow showed a direct correlation( r =0.824, P <0.01). Conclusion γ-radiation inhibits bFGF,VEGF expressions in bone marrow,suggesting that the abnormal expressions were ralated to the injury of hematopoietic microenvironment(HIM)cause by γ-radiation. |
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