| 朱寿彭,胡启跃,孙保福,杨卫东.不同辐射体核素诱发生殖细胞各发育期突变效应比较研究[J].中华放射医学与防护杂志,2004,24(3):196-198 |
| 不同辐射体核素诱发生殖细胞各发育期突变效应比较研究 |
| Comparative study of mutagenic effect on reproductive cells in each growth stage induced by different radiators |
| 投稿时间：2003-10-16 |
| DOI： |
| 中文关键词: 不同辐射体 生殖细胞 突变效应 睾丸 滞留 |
| 英文关键词:Different Radiators Reproductive cells Mutagenic effect Testis Retention |
| 基金项目:国家核工业科学基金资助项目(Y7197Q6206) |
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| 中文摘要: |
| 目的 探讨了α辐射体235U、β辐射体147Pm和γ辐射体134Cs诱发生殖细胞各发育期突变效应比较研究。方法 观察在不同辐射体核素作用下, 在睾丸的滞留方程、诱发生殖细胞各发育期的精原细胞和初级精母细胞染色体畸变以及精子畸形发生。比较3种辐射体核素在每cGy累积吸收剂量水平诱发的生殖细胞各发育期的突变效应值。结果 拟合了α、β和γ3种核素在睾丸中的滞留分数方程, 观察到235U的半滞留期为197d;147Pm为76d;134Cs为5.1 d.并给出了3种辐射体核素在每cGy累积吸收剂量水平诱发各发育期生殖细胞的突变效应比较值:精原细胞是α:β:γ=29:4:1;初级精母细胞为22:4:1;而对精子为α:β:γ=28:3:1.结论 235U,147Pm和134Cs均能诱发各发育期生殖细胞突变效应, 但诱发各发育期生殖细胞的突变效应比较值235U最为严重, 147Pm 次之134Cs诱发的程度最轻。 |
| 英文摘要: |
| Objective In this paper a comparative study of mutagenic effect on reproductive cells in each growth stage induced by α radiator 235 U,β radiator 147 Pm,and γ radiator 134 Cs was reported. Methods The equations fitted to describe the retentive fractions of different radiators in testis were observed.Chromosome aberrations were used to identify the expression of mutagenic effect in spermatogonia and primary spermatocytes.Sperm abnormality was also used to show the mutagenesis of sperm,so as to compare the rates of mutagenic effect induced by 1 cGy cumulative absorption dose of different radiators. Results The retentive half-life components of different radiatiors in testis were calculated to be T12 =197 d for 235 U,T12 =76 d for 147 Pm and only 5.1 d for 134 Cs.By comparison between different radiators,the mutagenic effect in spermatogonia induced by 1 cGy cumulative absorption dose was significantly different:the comparative value of mutagenesis of spermatogonia was α:β:γ=29:4:1;of primary spermatocytes was 22:4:1; and of sperm was α:β:γ=28:3:1. Conclusion Different radiators 235 U, 147 Pm and 134 Cs all could exert mutagenic effect on rèproductive cells in each growth stage,but the induction effect of α radiator 235U is the biggest,β radiator 147 Pm comes next and finally the γ radiator 134 Cs. |
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