| 鞠永健,陈美华,孙福印,等.放疗中评估不同剂量分布治疗方案效果的方法比较[J].中华放射医学与防护杂志,2004,24(2):133-135.JU Yong-jian,CHEN Mei-hua,SUN Fu-yin,et al.Comparison between evaluating methods about the protocols of different dose distributions in radiotherapy[J].Chin J Radiol Med Prot,2004,24(2):133-135 |
| 放疗中评估不同剂量分布治疗方案效果的方法比较 |
| Comparison between evaluating methods about the protocols of different dose distributions in radiotherapy |
| 投稿时间：2003-01-18 |
| DOI： |
| 中文关键词: 肿瘤控制概率 等效均匀剂量 放射治疗 剂量 |
| 英文关键词:Tumor control probability Equivalent uniform dose Radiotherapy Dose |
| 基金项目:国家自然科学基金资助项目(39670228) |
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| 中文摘要: |
| 目的 比较肿瘤控制概率(TCP)及等效均匀剂量(EUD)在评估不同剂量分布治疗方案时受生物学参数取值变化的影响程度。方法 根据TCP和EUD的定义推出各自的计算公式。假设治疗后肿瘤内的剂量为正态分布,将肿瘤分为很多体积相等的小体元,用蒙特卡罗方法对这些小体元的剂量进行模拟,根据计算画出不同放射敏感性(α)及克隆源性细胞倍增时间(Tp)取值时的TCP或EUD与剂量取值标准差(Sd)之间的关系曲线进行分析。结果 TCP与Sd的关系曲线受肿瘤生物学参数取值的影响较大,而EUD与Sd的关系曲线则基本不受影响。结论 在对不同病人间剂量不均匀分布的治疗方案进行比较时,如果已经准确获得了肿瘤生物学参数的取值,则使用TCP方法较好,否则应使用EUD方法。 |
| 英文摘要: |
| Objective To study the relationship between tumor control probability (TCP) or equivalent uniform dose (EUD) and the heterogeneity degree of the dose changes with variable biological parameter values of the tumor. Methods According to the definitions of TCP and EUD, calculating equations were derived. The dose distributions in the tumor were assumed to be Gaussian ones. The volume of the tumor was divided into several voxels, and the absorbed doses of these voxels were simulated by Monte Carlo methods. Then with the different values of radiosensitivity (α) and potential doubling time of the clonogens (Tp), the relationships between TCP or EUD and the standard deviation of dose (Sd) were evaluated. Results The TCP-Sd curves were influenced by the variable α and Tp values, but the EUD-Sdcurves showed little variation. Conclusion When the radiotherapy protocols with different dose distributions are compared, if the biological parameter values of the tumor have been known exactly, it's better to use the TCP, otherwise the EUD will be preferred. |
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