| 韩俊庆,李冠贞,杨哲,洪士强,杨菁,张振美,李学芹,曲风声.甘氨双唑钠对肺鳞癌放射增敏的临床前瞻性研究[J].中华放射医学与防护杂志,2004,24(1):44-46 |
| 甘氨双唑钠对肺鳞癌放射增敏的临床前瞻性研究 |
| A prospective clinical study of radiosensitization on lung squamous carcinoma by CMNa |
| 投稿时间：2003-05-08 |
| DOI： |
| 中文关键词: 肺鳞癌 甘氨双唑钠 放射增敏 |
| 英文关键词:Lung squamous carcinoma CMNa Radiosensitization |
| 基金项目: |
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| 中文摘要: |
| 目的 通过对肺鳞癌放射增敏的临床研究,探讨甘氨双唑钠(CMNa)放射增敏的治疗效果。方法 402例肺鳞癌患者随机分为放射增敏组和对照观察组,放射增敏组病人在放疗过程中,分别给予CMNa1200mg/m2静脉滴注0.5h,同步给予对照组病人生理盐水250ml静脉滴注,观察两组患者不同的近期疗效。结果 肿瘤原发病灶CR率与CR+PR率在两组之间差异有显著性,原发病灶达CR时吸收剂量明显低于对照组。两组患者治疗前后血常规和肝肾功能的检查结果、治疗中和治疗后不良反应及严重程度的比较无统计学意义。结论 CMNa可提高肺鳞癌的CR率和总有效率,并可降低肿瘤达到CR和PR时所需的吸收剂量。 |
| 英文摘要: |
| Objective To explore the curative effect of radiosensitization by CMNa through clinical prospective study on lung squamous carcinoma treated by radiotherapy. Methods A total of 402 patients with lung squamous carcinoma were divided into a radiosensitization group (CMNa+radiotherapy) and a control group (radiotherapy only) randomly by double blind method according to the ratio of 2∶1.Patients of the radiosensitization group was given CMNa 1200mg/m2 iv drip in 60 minutes before radiotherapy and those of the control group was given NS two times per week.The curative effects of these two groups were observed,in which the same foundational factors and treatment conditions in the course of radiotherapy were applied. Results There were significant differences in primary lesions on the rate of CR and CR+PR between these two groups.For CR of primary lesion,the radiation dose of radiosensitizition group was significantly lower than that of the control group.There were no statistical significances between these two groups on the kinds,severity and the rate of side-effect by laboratory test of blood routine,liver and kidney functions and clinical symptoms during and at the end of treatment. Conclusion The significant difference in curative effect between these two groups indicates the CR and the total effective rate can be increased and the irradiation dose can be reduced by using CMNa.No obviously side-effects are found in the digestive tract and nervous system under the recommended clinical dose. |
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