| 梁军,赵建东.高-低氧放疗对小鼠小肠上皮放射效应的影响[J].中华放射医学与防护杂志,2004,24(1):34-36 |
| 高-低氧放疗对小鼠小肠上皮放射效应的影响 |
| Effects of carbogen plus low concentration oxygen radiotherapy on murine intestinal epithelium |
| 投稿时间：2003-07-15 |
| DOI： |
| 中文关键词: 高-低氧放疗 小鼠小肠上皮 放射防护 |
| 英文关键词:Carbogen plus low concentration oxygen radiotherapy Murine intestinal epithelium Radioprotective effect |
| 基金项目:青岛科学技术委员会基金资助项目(200028) |
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| 中文摘要: |
| 目的 观察X射线照射时,给予高低氧对小鼠小肠上皮生物效应的影响。方法 昆明小鼠随机分为空气组、高氧组、低氧组、高低氧组。用6MVX射线不同剂量全腹腔单次照射。配合剂量效应曲线,求出不同吸氧方式的放射防护系数(RPF)。结果 高氧组、低氧组RPF分别为0.79,1.25。高低氧组照射表现出一定的放射防护作用,其RPF为1.06。结论 高低氧放疗消除了碳合氧吸入加重的小肠上皮的放射损伤,在一定程度上还具有放射防护作用。 |
| 英文摘要: |
| Objective To investigate the effects of carbogen plus low concentration oxygen radiotherapy on murine intestinal epithelium. Methods Kun Ming mice were divided into four groups:Air,HO,LO and HO+ LO.The abdomen of mice was irradiated with 6 MV X-rays at different single doses.The relationship between total cell survival per circumference and radiation dose was established,and dose-survival curves were fitted.Radioprotective factors(RPFs) were calculated. Results The RPF of groups HO,LO and HO+LO was 0.79,1.25 and 1.06,respectively. Conclusion Inhalation of low concentration oxygen can eradicate the enhanced damage by carbogen and possesses certain radioprotective effect. |
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