| 吴晓旻,杨明亮,黄晓兰,阎俊,罗琼.褐藻糖胶对照射大鼠免疫功能和淋巴细胞凋亡影响[J].中华放射医学与防护杂志,2003,23(6):430-432 |
| 褐藻糖胶对照射大鼠免疫功能和淋巴细胞凋亡影响 |
| Effect of fucoidan on splenic lymphocyte apoptosis induced by radiation |
| 投稿时间：2002-12-24 |
| DOI： |
| 中文关键词: 褐藻糖胶 照射 免疫调节 淋巴细胞 凋亡 |
| 英文关键词:Fucoidan Irradiation Immunoregulation Lymphocyte Apoptosis |
| 基金项目:湖北省科技厅重大攻关资助项目(2001AA307B) |
|
| 摘要点击次数: 2836 |
| 全文下载次数: 1761 |
| 中文摘要: |
| 目的 研究不同剂量褐藻糖胶对受γ射线照射大鼠免疫功能影响的作用机理。方法 不同剂量褐藻糖胶经口给予实验组大鼠,连续给药10d后行一次性60Coγ射线照射,18h后测定各组大鼠体液免疫、细胞免疫和非特异性免疫相关指标,并测定大鼠脾淋巴细胞凋亡率。结果 100mg/kg褐藻糖胶即能显著提高照射后大鼠T、B淋巴细胞增殖能力、巨噬细胞吞噬功能、血清溶血素含量,增强大鼠迟发性超敏反应,抑制照射后脾淋巴细胞凋亡,并呈现剂量效应关系,与阳性对照组比较差异有非常显著性(P<0.01)。结论 褐藻糖胶是一种抗照射免疫调节剂,对照射后大鼠的免疫系统具有恢复作用,其抗照射作用与抑制淋巴细胞凋亡有关。 |
| 英文摘要: |
| Objective To investigate the effect of immunologic function of fucoidan at different doses given preventively to rats exposed to γ-rays and its mechanism. Methods The Wistar rats were given fucoidan at different doses o rally for 10 d before whole-body irradiation with 60Coγ-rays.The r elated indexes of humoral,cellular and nonspecific immunologic functions and apo ptosis ratio of lymphocytes were measured 18 hs later. Results Fucoidan at 100 mg/kg was able to significantly enhance the ability of prolifera tion responses of T,B lymphocytes,the number and phagocytosis of macrophage,seru m hemolysin contents,the delayed type hypersensitivity response (DTH) of rats ex posed to γ-rays and to reduce apoptosis ratio of lymphocytes in irradiated rat s.There were dose-effect relationships in these observation indexes of the fuco idan groups.There were significant differences between these indexes of the fuco idan groups and those of the positive control group (P<0.01). Conclusion These results indicate that fucoidan as an immunoregulatory chemical could promo te the recovery of immunologic function in irradiated rats.The mechanism is asso ciated with the arrest of lymphocyte apoptosis by fucoidan. |
| HTML 查看全文 查看/发表评论 下载PDF阅读器 |
| 关闭 |
|
|
|