| 陈红红,胡昱兴,王英华,金美英,罗梅初,孙梅贞.邻苯二酚氨羧酸螯合剂对钍内污染延缓给药的效果[J].中华放射医学与防护杂志,2003,23(6):426-430 |
| 邻苯二酚氨羧酸螯合剂对钍内污染延缓给药的效果 |
| Protective effects of chelating agents of catechols amino carboxylic acid type on radiation injury induced by radiothorium in mice Ⅱ.delayed administration |
| 投稿时间：2002-11-11 |
| DOI： |
| 中文关键词: 邻苯二酚氨羧酸螯合剂 钍234 内照射损伤 脂质过氧化作用 促排 |
| 英文关键词:Chelating agent Thorium-234 Internal radiation injury Lipid peroxidation Decorporation |
| 基金项目:国家自然科学基金青年基金资助项目(39700039) |
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| 中文摘要: |
| 目的 进一步确证邻苯二酚氨羧酸螯合剂在体内的抗自由基作用,增进对核素内照射损伤的防护效果,及与促排效果之间的关系。方法 小鼠ip234Th06MBq/鼠3d后im螯合剂,连续3d,并以DTPA和VitE作促排效果和抗自由基作用的阳性对照,第8天处死动物检测整体和肝、骨中234Th蓄积量,骨髓有核细胞计数,骨髓、血清、肝匀浆MDA含量,观察骨髓、肝脏组织的病理变化。结果 9501、7601、DTPA延缓给药均仍有明显的促排效果,使整体234Th蓄积量比中毒组下降15%～16%,肝、骨蓄积量下降分别为中毒组的77%～79%和72%～75%,三者的效果相比差异无显著性,但明显低于即刻用药的效果。9501和7601能明显减轻234Th内污染小鼠的辐射损伤,骨髓有核细胞数,骨髓、肝脏MDA含量正常,未见明显的骨髓、肝脏的病理改变。而DTPA组的防护效果较差,出现较明显的骨髓组织损伤。VitE给药后第8天对减轻234Th所致骨髓、肝脏内照射损伤有一定的效果。结论 9501和7601对核素内照射损伤有明显的防护效果,具有促排和抗自由基作用的双重功能,是2个较理想的螯合剂,值得进一步研究。 |
| 英文摘要: |
| Objective To explore antioxidation efficacy of chelating agents (9501,7601) of catechols a m ino carboxylic acid type for radiothorium in vivo and relationship between t heir antioxidation and decorporation effects.To verify whether 9501 and 7601 could improve the protective effects for internal radiation injury. Methods The chelating agents were administered intramuscularly to ICR mice 3 days after intraperitoneal injection of 0 6 MBq 234Th-citrate for three consecutive days and the animals were sacrificed eight days late r.The 234Th radioactivity in the whole body and its retention in the l iver and skeleton were determined.The malondialdehyde (MDA) production as an ind ex of 234Th-induced lipid peroxidation in bone marrow and liver was a ssayed and the numbers of bone marrow nucleated cells (NBMNC) were counted.The p athological changes of bone marrow and liver tissue were observed. Results When 9501 and 7601 and DTPA were postponed to administer to 234Th-inc orpo rated mice,the whole body radioactivity was only decreased by 15%-16% and the r etention of 234Th in the liver, and skeleton was reduced to 77%-79% a n d 72%-75% as compared with the control group,respectively.They showed the simil ar removal effectiveness which was significantly lower than that when administed promptly.However,9501 and 7601 could inhibit 234Th-induced lipid peroxid ation,causing significant reduction of MDA content in bone marrow and liver, and markedly ameliorate histopathological changes of bone marrow and liver tissue in 234Th-treated mice.DTPA appeared to have a lower effectiveness.VitE hadn’t decorporation activity and slightly alleviated internal radiation injury. Conclusion The chelating agents 9501 and 7601 of catechols amino c arboxylic acid type have double functions of more effective decorporation and an tioxidation and can improve the curative effects.They are worth further investig ation. |
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