| 程光惠,姜德福,王铁军,等.Ⅲ期乳腺癌综合治疗的前瞻性研究[J].中华放射医学与防护杂志,2003,23(5):346-348.CHENG Guanghui,JIANG Defu,WANG Tiejun,et al.A randomized prospective study on combined treatment of patients with stage-Ⅲ breast cancer[J].Chin J Radiol Med Prot,2003,23(5):346-348 |
| Ⅲ期乳腺癌综合治疗的前瞻性研究 |
| A randomized prospective study on combined treatment of patients with stage-Ⅲ breast cancer |
| 投稿时间：2002-09-15 |
| DOI： |
| 中文关键词: 乳腺肿瘤 外科手术 放射治疗 化疗 |
| 英文关键词:Breast neoplasms Surgery Radiotherapy Chemotherapy |
| 基金项目: |
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| 摘要点击次数: 3196 |
| 全文下载次数: 2055 |
| 中文摘要: |
| 目的 探讨提高Ⅲ期乳腺癌疗效的方法。方法 前瞻性随机分组,85例Ⅲ期乳腺癌患者分为3组,A组28例(化疗+手术+放疗),放疗后配合辅助化疗;B组28例(手术+化疗+放疗);C组29例(手术+放疗+化疗)。观察各组的5年生存率、局部区域复发率和远处转移率差异有无显著性。结果 全部病例5年生存率为57.65%,局部区域复发率为18.82%,远处转移率为18.82%。各组5年生存率分别为75.00%、53.57%、44.83%,A组与C组比较差异有显著性(P<0.05)。各组局部区域复发率分别为7.14%、32.14%、17.24%,其中A组与B组比较差异有显著性(P<0.05)。各组远处转移率分别为7.14%、10.71%、37.93%,A组与C组及B组与C组间比较差异均有显著性(P<0.05)。结论 术前化疗再手术配合术后放疗及辅助化疗可提高Ⅲ期乳腺癌疗效。 |
| 英文摘要: |
| Objective To evaluate the curative effect of three different kinds of treatment for patients with stage-Ⅲ breast cancer. Methods Eighty patients with stage-Ⅲ breast cancer were randomized into three different groups:28 were treated by preoperative chemotherapy,combined with surgery and radiotherapy (group A);28 by surgery combined with chemotherapy and radiotherapy (group B);and 29 by surgery combined with radiotherapy and chemotherapy (group C).Differences in local regional recurrence,distant metastasis and 5-year survival rate were analysed for the three groups. Results The five-year survival rates were 57.65%,75.00%,53.57%,44.83% for the whole series and groups A,B,C,respectively.The difference was statistically significant between groups A and C (P<0.05).The local regional recurrence rates were 18.82%,7.14%,32.14%,17.24% for the whole series and groups A,B,C,respectively.The difference was statistically significant between groups A and B (P<0.05).The distant metastasis rates were 18.82%,7.14%,10.71%,37.93% for the whole series and groups A,B,C,respectively.The difference was statistically significant between groups A or B and C(P<0.05). Conclusion Preoperative chemotherapy plus surgery and followed by radiotherapy may improve the outcome of stage-Ⅲ breast cancer. |
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