| 岳麓,桂律,陈红红,罗伟华,徐萍,刘伟琪,程文英.125I植入对小鼠移植性实体瘤抑制效果[J].中华放射医学与防护杂志,2003,23(5):314-316 |
| 125I植入对小鼠移植性实体瘤抑制效果 |
| Research on the inhibitory effect of interstitial brachytherapy with 125I seeds in treatment of solid tumors in mice |
| 投稿时间：2002-12-15 |
| DOI： |
| 中文关键词: 125I籽源 组织间植入 艾氏腹水瘤细胞 |
| 英文关键词:125I seeds Interstitial brachytherapy Ehrlich ascite tumor cells |
| 基金项目:上海市科技发展基金资助项目(994119002) |
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| 摘要点击次数: 2964 |
| 全文下载次数: 2031 |
| 中文摘要: |
| 目的 观察125I籽源组织间植入对小鼠移植性实体瘤的治疗效果。方法 建立小鼠艾氏腹水瘤细胞移植性实体肿瘤模型。治疗组在肿瘤组织内平均植入4粒表面放射活性为814MBq的BT-125-Ⅰ型125I籽源,对照组植入4粒无放射活性的空心籽源。治疗28d,记录小鼠存活率。处死存活的小鼠,测量残存肿瘤的体积、重量并计算肿瘤体积抑制率。对摘除的肿瘤组织进行常规病理切片检查,观察籽源对肿瘤组织的破坏程度和范围。结果 治疗28d,治疗组和对照组小鼠存活率分别为75%和50%;平均瘤重分别为(0.347±0.25)g,(5.162±1.75)g(t=6.164,P<0.05);肿瘤平均体积分别为(175.9±147.9)mm3,(3974.1±1507.7)mm3(t=5.618,P<0.05),肿瘤体积抑制率为95.6%。常规病理切片结果显示,125I籽源周围0～3mm范围内肿瘤细胞病理变化由凝固坏死向外逐渐减弱为变性坏死;空心籽源周边区域仅有机械刺激导致的轻微水肿和纤维化。结论 125I籽源组织间植入对小鼠实体肿瘤具有显著的治疗效果。 |
| 英文摘要: |
| Objective To study the inhibitory effect of interstitial brachytherapy with 125I seeds in treatment of solid tumors in mice. Methods Solid tumor-bearing mice were produced with Ehrlich ascites tumor cells (EAC) and were divided into a treatment group (n=12) and a control group (n=10). In each mouse of the treatment group, four BT-125-Ⅰ Model 125I seeds with apparent activity of 8.14 MBq were implanted into the tumor; whereas in each mouse of the control group four dummy seeds were implanted. The mice survival rates of both groups were recorded after 28 days. The tumor weights and dimensions of survived mice were measured; tumor volume inhibition rate was calculated. T-test was performed to compare differences of tumor weights and volumes between these two groups. Routine pathological slides of tumor tissue were observed under light microscope to evaluate the range of tumor tissues damaged by 125I seeds. Results The survival rate of the treatment group was 75% and that of control group was 50%; the average weights of tumors of these two groups were (0.347±0.249)g and (5.162±1.749)g, respectively( t=6.164,P<0.05); and the average volumes of tumors were (175.9±147.9)mm3 and (3974.1±1507.7)mm3, respectively( t=5.618,P<0.05). The tumor volume inhibition rate was 95.6%. Pathological examination showed coagulative necrosis and degenerative necrosis dramatically presented at the range of 1 mm to 3 mm distance to active 125I seeds. No pathological changes but slight edema and fibroplasia were observed at the periphery of dummy seeds. Conclusion The visible effective radius of 125I seeds used in this study was about 3 mm on pathological slides of tumor tissue. The interstitial brachytherapy with 125I seeds could significantly inhibit the growth of EAC solid tumor of mice. |
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