中华放射医学与防护杂志

韦鹏翔,陈旭,艾泉山,等.X刀分次治疗帕金森病的临床应用[J].中华放射医学与防护杂志,2003,23(4):280-282.WEI Pengxiang,CHEN Xu,AI Quanshan,et al.The clinical research on fractionated irradiation treatment with X knife in patients of PD[J].Chin J Radiol Med Prot,2003,23(4):280-282

X刀分次治疗帕金森病的临床应用

The clinical research on fractionated irradiation treatment with X knife in patients of PD

投稿时间：2003-04-09

DOI：

中文关键词: 立体定向神经外科 X刀分次治疗帕金森病

英文关键词:SRNS X knife FIT PD

基金项目:解放军科研基金资助项目(2000);吉林省卫生厅基金资助项目(1998)

作者	单位
韦鹏翔	100050, 北京友谊医院神经外科
陈旭	100050, 北京友谊医院神经外科
艾泉山	100050, 北京友谊医院神经外科
夏吉勇	100050, 北京友谊医院神经外科
杨炯达	北京天坛医院神经外科
陈炳桓	北京天坛医院神经外科

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中文摘要:

目的探讨帕金森病(PD)的X刀分次治疗方法,为PD找出一条可行的无创治疗途径。方法 16例难治性PD病人,采用X刀140Gy分2次损毁丘脑腹外侧核中间部(VIM)治疗;8例病人采用165Gy分3次损毁VIM核治疗;每次间隔24h。结果 X刀治疗后3～24个月随访,24例病人消除或改善了震颤症状;僵直或运动减少症状不同程度的缓解;无并发症发生。神经生理学检查无显著改善。结论 X刀分次损毁VIM核,可安全、无创治疗PD;震颤症状改善显著。

英文摘要:

Objective To explore X knife treatment methods and to seek a new effective way for PD therapy. Methods Sixteen patients of PD were treated by performing VIM with 2 times of X knife fractionated irradiation (interval, 24 h) to a total dose of 140 Gy, and 8 patients of PD were treated by performing VIM with 3 times of X knife fractionated irradiation (interval, 24 h) to a total of dose of 165 Gy. Results During 3-24 months follow-up after X knife treatment, tremor was stopped in 19 patients and was relived significantly in 5 patients. Rigidity and bradykinesia of PD were relieved slightly. No complications were observed. Conclusion To perform VIM with X knife fractionated irradiation can be safely and effectively used to treat PD. The tremor of PD can be relieved slightly.

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