中华放射医学与防护杂志

徐鹭英,谢云青,宋墨琴,等.SOD药膜预防治疗急性放射性口腔炎的临床观察[J].中华放射医学与防护杂志,2003,23(4):273-275.XU Luying,XIE Yunqing,SONG Moqin,et al.Effect of SOD on acute radiation stomatitis[J].Chin J Radiol Med Prot,2003,23(4):273-275

SOD药膜预防治疗急性放射性口腔炎的临床观察

Effect of SOD on acute radiation stomatitis

投稿时间：2003-03-26

DOI：

中文关键词: 鼻咽癌放射性口腔炎超氧化物歧化酶

英文关键词:Nasopharyngeal neoplasms Radiation stomatitis Superoxide dismutase

基金项目:

作者	单位
徐鹭英	350014 福州, 福建省肿瘤医院放疗科
谢云青	350014 福州, 福建省肿瘤医院放疗科
宋墨琴	350014 福州, 福建省肿瘤医院放疗科
卢林	350014 福州, 福建省肿瘤医院放疗科
陈文娟	350014 福州, 福建省肿瘤医院放疗科

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中文摘要:

目的探讨超氧化物歧化酶(SOD)对急性放射性口腔炎的临床价值。方法 90例首程放疗鼻咽癌病人随机分为3组:A组用自制的SOD药膜;B组用维斯克药液;C组不行任何治疗。所有病人均于第2周末开始观察、用药,直至放疗第6周末。结果 A组放射性口腔炎的发病率明显低于C组(P<0.05);A组放射性口腔炎的有效率明显高于C组(P<0.01)。结论 SOD对急性放射性口腔炎有明显预防及治疗作用。

英文摘要:

Objective To evaluate the effect of superoxide dismutase(SOD) on stomatitis induced by radiation. Methods Altogether 90 nasopharyngeal carcinoma patients who accepted radiotherapy for the first time were randomized into 3 groups: group A-Application of the SOD drug made by our hospital; group B-Application of the drug “Weisike"; group C-The patients were untreated .All patients of groups A and B took the drugs two weeks after beginning of radiotherapy until the end of the sixth week. Results The rate of radiation stomatitis was obviously lower in group A than that in group C (PP<0.05), and the rate of healing was obviously higher (PP<0.01). Conclusion SOD is effective in prevention and treatment of radiation stomatitis.

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