| 白玉书,黄绮龙,马剑锋,等.重离子12C对60Coγ射线诱发人染色体畸变效应的比较研究[J].中华放射医学与防护杂志,2003,23(4):258-260.BAI Yushu,HUANG Qilong,MA Jianfeng,et al.A comparative study on biological effectiveness of chromosomal aberrations induced by heavy ion versus 60Co γ-rays in human peripheral blood lymphocytes[J].Chin J Radiol Med Prot,2003,23(4):258-260 |
| 重离子12C对60Coγ射线诱发人染色体畸变效应的比较研究 |
| A comparative study on biological effectiveness of chromosomal aberrations induced by heavy ion versus 60Co γ-rays in human peripheral blood lymphocytes |
| 投稿时间：2002-12-10 |
| DOI： |
| 中文关键词: 重离子 离体人血 剂量-效应曲线 相对生物效能 |
| 英文关键词:Heavy ion Human blood in vitro Dose-respond curve Relative biological effectiveness |
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| 中文摘要: |
| 目的 重离子和高剂量率60Coγ射线照射离体人血建立染色体畸变的剂量效应曲线;比较重离子12C照射与60Coγ射线照射诱发染色体畸变的相对生物效能。方法 重离子12C和60Coγ射线照射离体人血,吸收剂量率为3Gy/min,吸收剂量为1.0～8.0Gy。主要记录染色体型畸变的非稳定性畸变,对双着丝粒体和着丝粒环做曲线拟合,并检验回归系数的显著性和曲线的拟合度。结果 重离子12C和60Coγ射线照射离体血诱发的染色体畸变(双+环),在0～8Gy范围内,呈良好的剂量效应关系。12C离子诱发染色体畸变的RBE值是不恒定的,它随吸收剂量增加而减少,在0.3～8.0Gy范围内,RBE值(Dγ/Dc)从262到1.00,平均1.58。结论 12C离子对60Coγ射线照射诱发染色体畸变,在照射剂量较低时,有较高的生物效应。 |
| 英文摘要: |
| Objective To compare the effectiveness of heavy ion versus 60Coγ-rays in producing chromosomal aberrations in human lymphocytes. Methods Heparinized whole blood samples were exposed to heavy ion 12C and 60Coγ-rays, respectively.Unstable chromosomal aberrations including acentric fragments, minutes, acentric rings, dicentrics and centric rings(“dic+r”) were scored.Relative biological effectiveness (RBE) values of “dic+r” were derived. Results Chromosomal aberrations (“dic+r”) induced by either heavy ion 12C or 60Coγ-rays had a good dose-response relationship.Their best fitiing regression equations were PY=0.858503D+0.36154×10-2D2 (PR=0.9840) and PY=0.269792D+7.73083×10-2D2 (PR=0.9920), respectively.RBE values of heavy ion at 0.3-8.0 Gy ranged from 2.62 to 1.0, with an average of 1.58. Conclusion Heavy ion 12C has higher biological effectiveness in inducing chromosomal aberrations. |
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