| 何贵金,张申众,金永柏,等.103Pd放射性支架持续照射犬胆管的放射性损伤的实验研究[J].中华放射医学与防护杂志,2003,23(3):178-179.HE Guijin,ZHANG Shengzhong,JING Yongbai,et al.Radiation injury of canine bile duct induced by 103Pd metal stent[J].Chin J Radiol Med Prot,2003,23(3):178-179 |
| 103Pd放射性支架持续照射犬胆管的放射性损伤的实验研究 |
| Radiation injury of canine bile duct induced by 103Pd metal stent |
| 投稿时间：2002-10-31 |
| DOI： |
| 中文关键词: 胆管 辐射效应 病理学 胆管腔内照射 |
| 英文关键词:Bile duct Radiation effects Pathology Brachytherapy |
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| 中文摘要: |
| 目的 寻找动物胆管金属内支架植入方法,观察动物胆管植入103Pd放射性支架,胆管腔内照射的放射性损伤。方法 实验动物为雄性健康杂种犬,体重15～20kg。麻醉下经手术植入103Pd放射性金属支架于犬的胆管腔内,103Pd的放射性活度分别为12.5×104kBq、16.6×104kBq、22.2×104kBq、25.9×104kBq、29.6×104kBq和3.7×105kBq,植入后30d取出103Pd放射性金属支架和胆管,后者经组织切片HE染色,光镜下进行放射性损伤的评价。结果 放射性活度为12.5×104kBq,光镜下可观察到黏膜损伤;放射性活度为22.2×104kBq时胆管放射性损伤达肌层;放射性活度为3.7×105kBq时放射性损伤达胆管壁外膜,出现胆管穿孔。根据不同放射性活度照射后,胆管的放射性损伤的放射性活度效应曲线得出,ED50为28.2×104kBq。结论 103Pd金属支架胆管腔内近距离照射有明显的剂量效应关系,为该放射性支架应用于临床治疗胆管良、恶性狭窄提供重要的实验依据。 |
| 英文摘要: |
| Objective To assess radiation injury of dog bile duct induced by 103Pd metal stent. Methods Hybrid dogs with body weight form 15 to 20 kg were used. 103Pd metal stent was implanted into the common bile duct under anaesthesia, and the irradiation doses by 103Pd were 12.5×104kBq, 16.6×104kBq, 22.2×104kBq, 25. 9×104kBq, 29.6×104kBq and 3.7×105kBq, respectively. Results Radiation injury on the mucosa of the bili duct was observed in 12.5×104kBq group, and the damage extended to the muscular layer in 22.2×104kBq group.Perforation of the bile duct was observed in 3.7×105kBq group.The dose-response curve of radiation injury at different doses of intra-biliary metal stent 103Pd showed the effective dose (ED50) to be 28.2×104kBq. Conclusion There is an obvious dose response relationship for in the 103Pd metal stent.our result is unimportant theoretical basis for application of 103Pd metal stent to clinical treatment of biliary cancer. |
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