| 雷苏文,苏旭,白玉书,王菊芳,马剑锋,黄绮龙,关树荣,李文建.重离子12C6+对60Coγ射线诱发淋巴细胞微核效应的比较研究[J].中华放射医学与防护杂志,2003,23(3):151-153 |
| 重离子12C6+对60Coγ射线诱发淋巴细胞微核效应的比较研究 |
| A comparative study on micronuclei production induced by carbon ion versus 60Coγ-rays in human peripheral blood lymphocytes |
| 投稿时间：2002-08-28 |
| DOI： |
| 中文关键词: 重离子束12C6+ 60Coγ射线 CB微核法 相对生物效能 |
| 英文关键词:Carbon ion 60Coγ-rays CB micronucleus method Relative biological effecitiveness |
| 基金项目:国家自然科学基金资助项目(10105012) |
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| 中文摘要: |
| 目的 比较重离子束12C6+对60Coγ射线照射人离体血诱发淋巴细胞微核的效应。方法 用60Coγ射线和地面加速器产生的重离子12C6+(平均LET为36.70keVμm),不同剂量照射离体人血,用CB微核法观察双核淋巴细胞的微核,计算重离子束12C6+对60Coγ射线的相对生物效能。结果 在0～6Gy剂量范围内,重离子束12C6+对60Coγ射线的相对生物效能在4.19～1.78之间,平均为2.56。结论 重离子束12C6+比60Coγ射线有更高的生物效应。 |
| 英文摘要: |
| Objective To compare the effectiveness of carbon ion versus 60Co γ rays in producing micronuclei in human peripheral blood lymphocytes. Method Heparinized whole blood samples were exposed to carbon ion and 60Co γ rays, respectively.Micronuclei in binuclear lymphocytes (CB method) were scored.Relative biological effectiveness (RBE) values were caluclated. Results RBE values of carbon ion decreased with increasing dose (ranged from 1.78 to 4.19 Gy).The average RBE value is 2 56. Conclusion Carbon ion has higher biological effectiveness in inducing micronuclei than 60Co γ-rays do. |
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