| 管宏,赵慧云,沈磊,等.血管生长抑制剂TNP-470合并放射增敏治疗肿瘤的研究[J].中华放射医学与防护杂志,2003,23(2):96-97.GUAN Hong,ZHAO Huiyun,SHEN Lei,et al.Observation on the combinative effect of angiogenesis inhibitor TNP-470 and radiosensitizer in fractionized radiotherapy of a xenograft tumor model[J].Chin J Radiol Med Prot,2003,23(2):96-97 |
| 血管生长抑制剂TNP-470合并放射增敏治疗肿瘤的研究 |
| Observation on the combinative effect of angiogenesis inhibitor TNP-470 and radiosensitizer in fractionized radiotherapy of a xenograft tumor model |
| 投稿时间：2002-03-26 |
| DOI： |
| 中文关键词: TNP-470 血管生长抑制剂 MISO 放射增敏剂 分次放疗 |
| 英文关键词:TNP-470 Angiogenesis inhibitor MISO Radiosensitizer Fractionized radiotherapy |
| 基金项目: |
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| 中文摘要: |
| 目的观察血管生长抑制剂TNP-470与放射增敏剂MISO在放疗中联合应用治疗肿瘤的效果。方法以Lewis肺癌荷瘤小鼠模型比较TNP-470与增敏放疗联合的治疗方法与其他相应各对比治疗方法的差异。结果TNP-470与放射增敏剂MISO在放疗中联合应用的治疗效果要明显好于其他治疗方法。结论血管生长抑制剂TNP-470能够增强放射增敏剂MISO对放疗的增敏效果。 |
| 英文摘要: |
| Objective To examine the combinative anti-tumor effect of angiogenesis inhibitor TNP-470 and radiosensitizer MISO in radiotherapy. Methods A 6-group in vivo experiment was conducted to evaluate the effects of TNP-470 combining γ-irradiation with or without MISO in the C57 mice bearing Lewis lung cancer. Results TNP-470 combined with γ-irradiation and MISO showed the best therapeutic effectiveness in vivo. Conclusion Angiogenesis inhibitor TNP-470 could potentiate the efficacy of radiosensitizer in radiotherapy. |
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