| 雷苏文,苏旭,白玉书,王菊芳,马剑锋,黄绮龙,关树荣,李文建.重离子束12C6+照射人离体血建立淋巴细胞微核的剂量-效应曲线[J].中华放射医学与防护杂志,2003,23(1):20-22 |
| 重离子束12C6+照射人离体血建立淋巴细胞微核的剂量-效应曲线 |
| The dose-effect curve of micronuclei established with human peripheral blood lymphocytes after irradiation with heavy ion beams 12C6+ |
| 投稿时间：2002-07-09 |
| DOI： |
| 中文关键词: 重离子束12C6+ CB微核法 剂量-效应曲线 |
| 英文关键词:Heavy ion beams 12C6+ CB micronucleus method Dose-effect curve |
| 基金项目:国家自然科学基金资助项目(10105012) |
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| 中文摘要: |
| 目的 研究建立重离子束12C6+照射人离体血诱发淋巴细胞微核的剂量效应曲线。方法 用地面加速器产生的重离子12C6+(平均LET为36.70keV/μm),不同吸收剂量、不同吸收剂量率照射离体人血,用CB微核法观察双核淋巴细胞中的微核。结果 在0～6Gy吸收剂量范围内,淋巴细胞微核率随吸收剂量的增加而增加,拟合的最佳方程为Y=665.09×D0.85.结论 12C6+照射人离体血诱发淋巴细胞微核在0～6Gy吸收剂量范围内呈幂函数关系。 |
| 英文摘要: |
| Objective To establish the dose-effect curve of micronuclei for human peripheral blood lymphocytes after irradiation with heavy ion beams 12C6+ . Methods Heparinized whole blood samples were irradiated with heavy ion beams 12C6+, having 2 different dose-rate values (dose-rate=1 Gy/min and 3 Gy/min, mean LET=36 70 keV/μm), accelerated by a Heavy Ion Research Facility in Lanzhou at the Institute of Modern Physics, Chinese Academy of Sciences.Micronuclei in binuclear lymphocytes (CB method) were scored. Results At the absorbed dose range of 0-6 Gy, the CB micronucleus frequency increased with the increase of absorbed dose.The best-fitted equation is Y=665 09×D0 .85 . Conclusion At the absorbed dose range of 0-6 Gy, the relationship between absorbed dose and micronucleus frequency of human peripheral blood lymphocytes induced by heavy ion beams 12C6+ is exponential. |
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