中华放射医学与防护杂志

王明席,张良安,王永,等.⁹⁹Tc^m-MIBI在小鼠肝脏细胞核内的吸收剂量分布研究[J].中华放射医学与防护杂志,2002,22(5):377-379.WANG Mingxi,ZHANG Liang'an,WANG Yong,et al.A study of microscopic dose rate distribution of ⁹⁹Tc^m-MIBI in the liver of mice[J].Chin J Radiol Med Prot,2002,22(5):377-379

⁹⁹Tc^m-MIBI在小鼠肝脏细胞核内的吸收剂量分布研究

A study of microscopic dose rate distribution of ⁹⁹Tc^m-MIBI in the liver of mice

投稿时间：2001-07-02

DOI：

中文关键词: 微剂量吸收剂量率甲氧基异丁基异腈放射自显影医学内照射剂量

英文关键词:Microdosimetry Absorbed dose rate MIBI Autoradiography MIRD

基金项目:

作者	单位
王明席	100192 天津,中国协和医科大学中国医学科学院放射医学研究所
张良安	100192 天津,中国协和医科大学中国医学科学院放射医学研究所
王永	100192 天津,中国协和医科大学中国医学科学院放射医学研究所
戴光复	100192 天津,中国协和医科大学中国医学科学院放射医学研究所

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中文摘要:

目的尝试建立一种微剂量估算模式,评估靶细胞核对放射性药物的准确吸收剂量率。方法以⁹⁹Tc^m-甲氧基异丁基异腈(MIBI)为例,运用冰冻切片光镜放射自显影技术,观察小鼠尾静脉注射⁹⁹Tc^m-MIBI2h后,肝脏内放射性药物在亚细胞水平分布情况,探索一种符合实际分布情况的数学模式来估算肝细胞核的微剂量率,并与医学内照射剂量(MIRD)估算方式比较,判断两种剂量率估算方法的准确性。结果 ⁹⁹Tc^m-MIBI在肝脏亚细胞水平的分布是不均匀的,实际肝细胞核微剂量率数值与利用MIRD模式估算的结果差异有非常显着性(P<001).结论在⁹⁹Tc^m标记药物非均匀分布情况下,本文作者所建立的微剂量率估算模型,可替代MIRD,模式,较准确地估算微剂量率。

英文摘要:

Objective A microdosimetry model was tried to develop an accurate way to evaluate absorbed dose rates in target cell nuclei from radiopharmaceuticals. Methods Microscopic frozen section autoradiography was used to determine the subcellular locations of ⁹⁹ Tc^m- MIBI relative to the tissue histology in the liver of mice after injection of ⁹⁹ Tc m- MIBI via tail for two hours,and a mathematical model was developed to evaluate the microscopic dose rates in cell nuclei.The Medical Internal Radiation Dose(MIRD) schema was also used to evaluate the dose rates at the same time,and a comparison of the results of the two methods was conducted to determine which method is better to accurately estimate microscopic dose rates. Results The spatial distribution of ⁹⁹ Tc ^m- MIBI in the liver of mice at subcellular level was not uniform,and the differences between the microdosimetry model and MIRD schema were significant( P <0. 01). Conclusion The microdosimetry model established in this test could be used as a substitute for MIRD schema to evaluate the dose of not uniformly distributed ⁹⁹ Tc^m labeled pharmaceuticals at the microscopic level;

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